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  4. Recombinant Human AF4/FMR2 family member 1 (AFF1), partial

Recombinant Human AF4/FMR2 family member 1 (AFF1), partial

  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 1(AFF1) ,partial
  • 貨號：
    CSB-YP001412HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 1(AFF1) ,partial
  • 貨號：
    CSB-EP001412HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 1(AFF1) ,partial
  • 貨號：
    CSB-EP001412HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 1(AFF1) ,partial
  • 貨號：
    CSB-BP001412HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 1(AFF1) ,partial
  • 貨號：
    CSB-MP001412HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    AFF1
  • Uniprot No.：
  • 別名：
    AF 4; AF 4 protein; AF4; AF4-MLL; AF4/FMR2 family member 1; AFF 1; AFF1; AFF1_HUMAN; ALL1 fused gene from chromosome 4; ALL1-fused gene from chromosome 4 protein; FEL; MGC134969; MLL/AF4; MLLT2; myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila); translocated to; 2; MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2; PBM1; Pre B cell monocytic leukemia partner 1; Protein AF-4; Protein FEL; Proto-oncogene AF4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. Our study represents the first report assessing the association of AFF1 rs340630 polymorphism with rheumatoid arthritis risk. No significant evidence was found for the dominant or recessive models. PMID: 29791587
    2. Presence of fusion the genes BCR/ABL1, ETV6/RUNX1, and MLL/AF4 does not have any impact on the clinical and laboratory features of ALL at presentation. PMID: 26856288
    3. There was no association between AFF1 polymorphism (rs340630) and systemic lupus erythematosus. However, our findings indicated that AFF1 polymorphism (rs340630) was significantly (P=0.0045) correlated with renal disorder in Iranian population PMID: 27115110
    4. MLL-AF4 fusion is associated with acute myeloid leukemia. PMID: 28114278
    5. AF4 bindsto SL1 to initiate MLL fusion- and AEP-dependent transcription. PMID: 26593443
    6. AFF1 is a ubiquitous P-TEFb partner; full Tat transactivation requires the complete super elongation complexes PMID: 24367103
    7. The structure of AF9 in complex with elongation factor AF4 reveals that aliphatic residues form an integral part of the hydrophobic core of the complex. PMID: 23260655
    8. No association between AFF1 rs340630 and systemic lupus erythmatosus was found. PMID: 22983539
    9. we identified a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with Systemic lupus erythematosus susceptibility (rs340630; P = 8.3x10(-9), odds ratio = 1.21 PMID: 22291604
    10. our findings show AF4-dependent regulation of CD133 expression, which is required for the growth of acute lymphoblastic leukemia cells PMID: 22337994
    11. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AF4. PMID: 16215946
    12. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of AF4 chimeric oncogene. PMID: 16386788
    13. The early onset of distinct mixed lymphoid/myeloid lineage deregulation in Mll-AF4 knock-in mice shows evidence for both "instructive" and "noninstructive" roles for AF4 and AF9 as partners in MLL fusion genes. PMID: 16551973
    14. presence of both reciprocal MLL fusion proteins confers biological properties known from t(4;11) leukemia PMID: 17130830
    15. Gene rearrangement and genetic translocations observed in acute lymphoblastic leukemia. PMID: 17301807
    16. demonstrate coimmunoprecipitation of the All1/Af4 and All1/Af9 fusions with Drosha, disrupted by treatment with DNase I PMID: 17581865
    17. Conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic and acute myeloid leukemias PMID: 18977325

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  • 相關疾病：
    A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    AF4 family
  • 數據庫鏈接：

    HGNC: 7135

    OMIM: 159557

    KEGG: hsa:4299

    STRING: 9606.ENSP00000378578

    UniGene: Hs.480190



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