在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AFF1 Antibody

  • 中文名稱:
    AFF1兔多克隆抗體
  • 貨號:
    CSB-PA010201
  • 規(guī)格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    AFF1
  • 別名:
    AF 4 antibody; AF 4 protein antibody; AF4 antibody; AF4-MLL antibody; AF4/FMR2 family member 1 antibody; AFF 1 antibody; AFF1 antibody; AFF1_HUMAN antibody; ALL1 fused gene from chromosome 4 antibody; ALL1-fused gene from chromosome 4 protein antibody; FEL antibody; MGC134969 antibody; MLL/AF4 antibody; MLLT2 antibody; myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila); translocated to; 2 antibody; MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2 antibody; PBM1 antibody; Pre B cell monocytic leukemia partner 1 antibody; Protein AF-4 antibody; Protein FEL antibody; Proto-oncogene AF4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human AF-4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻:
    1. Our study represents the first report assessing the association of AFF1 rs340630 polymorphism with rheumatoid arthritis risk. No significant evidence was found for the dominant or recessive models. PMID: 29791587
    2. Presence of fusion the genes BCR/ABL1, ETV6/RUNX1, and MLL/AF4 does not have any impact on the clinical and laboratory features of ALL at presentation. PMID: 26856288
    3. There was no association between AFF1 polymorphism (rs340630) and systemic lupus erythematosus. However, our findings indicated that AFF1 polymorphism (rs340630) was significantly (P=0.0045) correlated with renal disorder in Iranian population PMID: 27115110
    4. MLL-AF4 fusion is associated with acute myeloid leukemia. PMID: 28114278
    5. AF4 bindsto SL1 to initiate MLL fusion- and AEP-dependent transcription. PMID: 26593443
    6. AFF1 is a ubiquitous P-TEFb partner; full Tat transactivation requires the complete super elongation complexes PMID: 24367103
    7. The structure of AF9 in complex with elongation factor AF4 reveals that aliphatic residues form an integral part of the hydrophobic core of the complex. PMID: 23260655
    8. No association between AFF1 rs340630 and systemic lupus erythmatosus was found. PMID: 22983539
    9. we identified a novel association of a variant in the AF4/FMR2 family, member 1 (AFF1) gene at 4q21 with Systemic lupus erythematosus susceptibility (rs340630; P = 8.3x10(-9), odds ratio = 1.21 PMID: 22291604
    10. our findings show AF4-dependent regulation of CD133 expression, which is required for the growth of acute lymphoblastic leukemia cells PMID: 22337994
    11. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AF4. PMID: 16215946
    12. The TCR gene rearrangements in childhood B-lineage acute lymphoblastic leukemia was associated with expression of AF4 chimeric oncogene. PMID: 16386788
    13. The early onset of distinct mixed lymphoid/myeloid lineage deregulation in Mll-AF4 knock-in mice shows evidence for both "instructive" and "noninstructive" roles for AF4 and AF9 as partners in MLL fusion genes. PMID: 16551973
    14. presence of both reciprocal MLL fusion proteins confers biological properties known from t(4;11) leukemia PMID: 17130830
    15. Gene rearrangement and genetic translocations observed in acute lymphoblastic leukemia. PMID: 17301807
    16. demonstrate coimmunoprecipitation of the All1/Af4 and All1/Af9 fusions with Drosha, disrupted by treatment with DNase I PMID: 17581865
    17. Conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic and acute myeloid leukemias PMID: 18977325

    顯示更多

    收起更多

  • 相關疾病:
    A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    AF4 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7135

    OMIM: 159557

    KEGG: hsa:4299

    STRING: 9606.ENSP00000378578

    UniGene: Hs.480190



主站蜘蛛池模板: 骚片av蜜桃精品一区| 狠狠色噜噜狠狠狠狠五月婷| 国产精品无码aⅴ嫩草| 99国产精品国产精品九九| 在线 无码 中文字幕 强 乱| 大j8黑人w巨大888a片| 国产l精品国产亚洲区| 国产精品免费无码二区 | 少妇被爽到高潮喷水久久欧美精品 | 92国产精品午夜福利免费| 国产成人无码视频一区二区三区| 丰满多毛的大隂户毛茸茸| 国产丰满乱子伦无码专区| 精品无码国产日韩制服丝袜 | 久久国产精品偷| 日韩精品人妻系列一区二区三区 | 欧美日韩在线视频一区 | 夜夜爽日日澡人人添| 欧美一夜爽爽爽爽爽爽| 国产精品国产av片国产| 日本xxxx18野外无毒不卡| 夜夜爽日日澡人人添| 国产精品 无码专区| 日韩精品无码一区二区三区视频| 手机在线亚洲国产精品| 天天躁日日躁狠狠躁性色avq| 九九久久精品国产av片国产| 亚洲欧美国产另类va| 精品国产av一区二区果冻传媒 | 亚洲国产成人最新精品| 无码喷水一区二区浪潮av| 国产av一区二区三区最新精品| 欧美成人精品手机在线| 日本久久综合久久综合| 精品亚洲aⅴ在线无码播放| 国产人妻人伦精品| 男女啪祼交视频| 亚洲国产成av人天堂无码| 99国产精品欧美一区二区三区 | 影音先锋人妻啪啪av资源网站| 亚洲 精品 制服 校园 无码|