在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human 72 kDa inositol polyphosphate 5-phosphatase (INPP5E)

  • 中文名稱:
    人INPP5E重組蛋白
  • 貨號:
    CSB-YP873641HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人INPP5E重組蛋白
  • 貨號:
    CSB-EP873641HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人INPP5E重組蛋白
  • 貨號:
    CSB-EP873641HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人INPP5E重組蛋白
  • 貨號:
    CSB-BP873641HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人INPP5E重組蛋白
  • 貨號:
    CSB-MP873641HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    5-bisphosphate 5-phosphatase; 72 kDa inositol polyphosphate 5-phosphatase; Inositol polyphosphate 5 phosphatase; INP5E_HUMAN; Inpp5e; Phosphatidylinositol (4,5) bisphosphate 5 phosphatase; Phosphatidylinositol 4; Phosphatidylinositol polyphosphate 5 phosphatase type IV; Phosphatidylinositol polyphosphate 5-phosphatase type IV; PPI5PIV
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-644
  • 氨基酸序列
    MPSKAENLRP SEPAPQPPEG RTLQGQLPGA PPAQRAGSPP DAPGSESPAL ACSTPATPSG EDPPARAAPI APRPPARPRL ERALSLDDKG WRRRRFRGSQ EDLEARNGTS PSRGSVQSEG PGAPAHSCSP PCLSTSLQEI PKSRGVLSSE RGSPSSGGNP LSGVASSSPN LPHRDAAVAG SSPRLPSLLP PRPPPALSLD IASDSLRTAN KVDSDLADYK LRAQPLLVRA HSSLGPGRPR SPLACDDCSL RSAKSSFSLL APIRSKDVRS RSYLEGSLLA SGALLGADEL ARYFPDRNVA LFVATWNMQG QKELPPSLDE FLLPAEADYA QDLYVIGVQE GCSDRREWET RLQETLGPHY VLLSSAAHGV LYMSLFIRRD LIWFCSEVEC STVTTRIVSQ IKTKGALGIS FTFFGTSFLF ITSHFTSGDG KVAERLLDYT RTVQALVLPR NVPDTNPYRS SAADVTTRFD EVFWFGDFNF RLSGGRTVVD ALLCQGLVVD VPALLQHDQL IREMRKGSIF KGFQEPDIHF LPSYKFDIGK DTYDSTSKQR TPSYTDRVLY RSRHKGDICP VSYSSCPGIK TSDHRPVYGL FRVKVRPGRD NIPLAAGKFD RELYLLGIKR RISKEIQRQQ ALQSQNSSTI CSVS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability.
  • 基因功能參考文獻:
    1. miR598 contributed to cell proliferation and cell cycle progression in colorectal carcinoma by targeting INPP5E. PMID: 29257251
    2. INPP5E associates with the N-terminus of RPGR and trafficking of INPP5E to cilia is dependent upon the ciliary localization of RPGR. PMID: 28172980
    3. we identify Inpp5e as an essential inhibitor of the PI3K/Akt/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD) suppression PMID: 27056978
    4. ARL13B regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E. PMID: 27927754
    5. In neuronal cells, INPP5E knockdown strongly inhibited autophagy by impairing the autophagosome-lysosome fusion step. PMID: 27340123
    6. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit. PMID: 28031327
    7. INPP5E is an essential point of convergence between Hedgehog and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog-dependent embryonic development. PMID: 27998989
    8. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis. PMID: 26916822
    9. These findings establish the first direct link between AURKA and phosphoinositide signaling and suggest that the function of INPP5E in cilia is at least partly mediated by its interactions with AURKA PMID: 25395580
    10. Proteomic analysis identified INPP5E, whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D. Mutant PDE6D shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues. PMID: 24166846
    11. Identification of 12 different INPP5E mutations in patients with Joubert syndrome with an overall 2.7% mutation frequency. PMID: 23386033
    12. findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins PMID: 23150559
    13. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in humans. PMID: 19668215
    14. Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. PMID: 19668216
    15. Functional analysis of the mouse counterpart. PMID: 10806194

    顯示更多

    收起更多

  • 相關疾病:
    Joubert syndrome 1 (JBTS1); Mental retardation, truncal obesity, retinal dystrophy, and micropenis (MORMS)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Cytoplasm. Nucleus.
  • 蛋白家族:
    Inositol 1,4,5-trisphosphate 5-phosphatase type IV family
  • 組織特異性:
    Detected in brain, heart, pancreas, testis and spleen.
  • 數據庫鏈接:

    HGNC: 21474

    OMIM: 213300

    KEGG: hsa:56623

    STRING: 9606.ENSP00000360777

    UniGene: Hs.120998



主站蜘蛛池模板: 亚洲午夜无码毛片av久久京东热| 999国内精品永久免费观看| 亚洲色精品三区二区一区| 成人欧美一区二区三区的电影| 色与欲影视天天看综合网| 奇米在线7777在线精品| 亚洲乱码中文字幕综合234| 老熟女高潮喷水了| 色一情一乱一伦一视频免费看| 国产情侣草莓视频在线| 亚洲中国最大av网站| 98视频精品全部国产| 午夜亚洲影院在线观看| 欧美精品在线观看| av香港经典三级级 在线| 黄页网站在线观看免费视频| 在线天堂免费观看.www| 中文有码亚洲制服av片| 成a人片亚洲日本久久| 久久久久精品无码一区二区三区| 综合自拍亚洲综合图区高清| 男女做爰猛烈叫床视频免费| 亚洲爆乳无码专区www| 国产在线观看高清视频黄网| 国产亚洲精品成人aa片| 欧美 国产 综合 欧美 视频| 无翼乌工口全彩肉肉无遮挡18| 香蕉在线 亚洲 欧美 专区 | www内射国产在线观看| 日韩人妻无码精品-专区| 精品一区二区三区免费播放| 爱色精品视频一区二区| 一区二区三区av高清免费波多| 亚洲第一无码精品立川理惠| 国产日韩精品欧美2020区| 日韩国产亚洲一区二区三区| 精品无码国产污污污免费| 亚洲欧美综合区丁香五月小说| 女学生14毛片视频片二毛| 手机看片久久国产免费| 少妇高潮毛片色欲ava片 |