在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

INPP5E Antibody, FITC conjugated

  • 中文名稱:
    INPP5E兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA873641LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) INPP5E Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    5-bisphosphate 5-phosphatase antibody; 72 kDa inositol polyphosphate 5-phosphatase antibody; Inositol polyphosphate 5 phosphatase antibody; INP5E_HUMAN antibody; Inpp5e antibody; Phosphatidylinositol (4,5) bisphosphate 5 phosphatase antibody; Phosphatidylinositol 4 antibody; Phosphatidylinositol polyphosphate 5 phosphatase type IV antibody; Phosphatidylinositol polyphosphate 5-phosphatase type IV antibody; PPI5PIV antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human 72 kDa inositol polyphosphate 5-phosphatase protein (1-133AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability.
  • 基因功能參考文獻:
    1. miR598 contributed to cell proliferation and cell cycle progression in colorectal carcinoma by targeting INPP5E. PMID: 29257251
    2. INPP5E associates with the N-terminus of RPGR and trafficking of INPP5E to cilia is dependent upon the ciliary localization of RPGR. PMID: 28172980
    3. we identify Inpp5e as an essential inhibitor of the PI3K/Akt/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD) suppression PMID: 27056978
    4. ARL13B regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E. PMID: 27927754
    5. In neuronal cells, INPP5E knockdown strongly inhibited autophagy by impairing the autophagosome-lysosome fusion step. PMID: 27340123
    6. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit. PMID: 28031327
    7. INPP5E is an essential point of convergence between Hedgehog and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog-dependent embryonic development. PMID: 27998989
    8. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis. PMID: 26916822
    9. These findings establish the first direct link between AURKA and phosphoinositide signaling and suggest that the function of INPP5E in cilia is at least partly mediated by its interactions with AURKA PMID: 25395580
    10. Proteomic analysis identified INPP5E, whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D. Mutant PDE6D shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues. PMID: 24166846
    11. Identification of 12 different INPP5E mutations in patients with Joubert syndrome with an overall 2.7% mutation frequency. PMID: 23386033
    12. findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins PMID: 23150559
    13. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in humans. PMID: 19668215
    14. Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. PMID: 19668216
    15. Functional analysis of the mouse counterpart. PMID: 10806194

    顯示更多

    收起更多

  • 相關疾病:
    Joubert syndrome 1 (JBTS1); Mental retardation, truncal obesity, retinal dystrophy, and micropenis (MORMS)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Cytoplasm. Nucleus.
  • 蛋白家族:
    Inositol 1,4,5-trisphosphate 5-phosphatase type IV family
  • 組織特異性:
    Detected in brain, heart, pancreas, testis and spleen.
  • 數據庫鏈接:

    HGNC: 21474

    OMIM: 213300

    KEGG: hsa:56623

    STRING: 9606.ENSP00000360777

    UniGene: Hs.120998



主站蜘蛛池模板: 久久成人伊人欧洲精品| 欧美疯狂性受xxxxx喷水| 日韩av高清无码| 无码熟熟妇丰满人妻啪啪 | 久久不见久久见免费视频6无删减| 国内野外强奷在线视频| 亚洲va在线∨a天堂va欧美va| 40岁成熟女人牲交片20分钟| 毛茸茸性xxxx毛茸茸毛茸茸| 2019久久视频这里有精品15| 国产精品卡一卡2卡三卡网站| 99精品众筹模特自拍视频| 欧美黑人又大又粗xxxxx| 高清无码一区二区在线观看吞精| 国产亚洲精品福利视频在线观看| 伊人久久大香线蕉无码不卡| 久久久久久久久久久久久9999 | 亚洲精品蜜桃久久久久久| 免费1级a做爰片观看| 97色成人综合网站| 极品少妇伦理一区二区| 亚洲色大成网站www永久| 东京道一本热中文字幕| 久久久久精品无码一区二区三区| 亚洲综合久久成人a片| 51国偷自产一区二区三区| 国产乱妇乱子在线播放视频| 成年网站未满十八禁视频天堂| 久久麻豆成人精品av| 国产成人综合久久亚洲精品| 在线成人a毛片免费播放| 太深太粗太爽太猛了视频免费观看| 精品丰满人妻无套内射| 久久久中文久久久无码| 免费两性的视频网站| 超清无码波多野吉衣中文| 中文无码vr最新无码av专区| 成人伊人亚洲人综合网站| 无码av不卡免费播放| 免费极品av一视觉盛宴| 99久久人妻无码精品系列|