在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. INPP5E Antibody, FITC conjugated

INPP5E Antibody, FITC conjugated

  • 中文名稱：
    INPP5E兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA873641LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) INPP5E Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    5-bisphosphate 5-phosphatase antibody; 72 kDa inositol polyphosphate 5-phosphatase antibody; Inositol polyphosphate 5 phosphatase antibody; INP5E_HUMAN antibody; Inpp5e antibody; Phosphatidylinositol (4,5) bisphosphate 5 phosphatase antibody; Phosphatidylinositol 4 antibody; Phosphatidylinositol polyphosphate 5 phosphatase type IV antibody; Phosphatidylinositol polyphosphate 5-phosphatase type IV antibody; PPI5PIV antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human 72 kDa inositol polyphosphate 5-phosphatase protein (1-133AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability.
  • 基因功能參考文獻：
    1. miR598 contributed to cell proliferation and cell cycle progression in colorectal carcinoma by targeting INPP5E. PMID: 29257251
    2. INPP5E associates with the N-terminus of RPGR and trafficking of INPP5E to cilia is dependent upon the ciliary localization of RPGR. PMID: 28172980
    3. we identify Inpp5e as an essential inhibitor of the PI3K/Akt/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD) suppression PMID: 27056978
    4. ARL13B regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E. PMID: 27927754
    5. In neuronal cells, INPP5E knockdown strongly inhibited autophagy by impairing the autophagosome-lysosome fusion step. PMID: 27340123
    6. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit. PMID: 28031327
    7. INPP5E is an essential point of convergence between Hedgehog and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog-dependent embryonic development. PMID: 27998989
    8. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis. PMID: 26916822
    9. These findings establish the first direct link between AURKA and phosphoinositide signaling and suggest that the function of INPP5E in cilia is at least partly mediated by its interactions with AURKA PMID: 25395580
    10. Proteomic analysis identified INPP5E, whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D. Mutant PDE6D shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues. PMID: 24166846
    11. Identification of 12 different INPP5E mutations in patients with Joubert syndrome with an overall 2.7% mutation frequency. PMID: 23386033
    12. findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins PMID: 23150559
    13. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in humans. PMID: 19668215
    14. Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. PMID: 19668216
    15. Functional analysis of the mouse counterpart. PMID: 10806194

    顯示更多

    收起更多

  • 相關疾病：
    Joubert syndrome 1 (JBTS1); Mental retardation, truncal obesity, retinal dystrophy, and micropenis (MORMS)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Cytoplasm. Nucleus.
  • 蛋白家族：
    Inositol 1,4,5-trisphosphate 5-phosphatase type IV family
  • 組織特異性：
    Detected in brain, heart, pancreas, testis and spleen.
  • 數據庫鏈接：

    HGNC: 21474

    OMIM: 213300

    KEGG: hsa:56623

    STRING: 9606.ENSP00000360777

    UniGene: Hs.120998



主站蜘蛛池模板： 国产精品天干在线观看| 久久精品成人免费国产| 亚洲爆乳成av人在线视菜奈实| 亚洲中文字幕无码中文| 欧美日产成人高清视频| 国产伦孑沙发午休精品| 人人妻人人澡人人爽超污| 欧美大片va欧美在线播放| 2021久久精品国产99国产精品| 国产山东熟女48嗷嗷叫| 99国产精品永久免费视频| 少妇性l交大片| 天天澡天天揉揉av无码| 日产精品一二三区| 欧美人与动性xxxxx杂性| 50岁退休熟女露脸高潮| 国产aⅴ爽av久久久久久| 韩国国内大量揄拍精品视频| 少妇人妻偷人精品视频| 国产98色在线 | 国产| 国产av久久人人澡人人爱 | 国产免费久久精品99reswag | 亚洲伊人久久综合影院| 日本久久久久久久做爰片日本| 一本天堂v无码亚洲道久久| 内射女校花一区二区三区| 无码成人一区二区三区| 狠狠色丁香婷婷综合尤物| 亚洲.日韩.欧美另类| 亚洲色成人中文字幕网站| 亚洲一区二区三区无码久久| 国产成人av一区二区三区无码| 极品新婚夜少妇真紧| 曰本女人与公拘交酡| 男人的天堂av社区在线| 国产精品女视频一区二区| 国产亚洲精品久久久网站好莱| 七七久久成人影院网站| 国语自产精品视频在线第100页 | 中文字幕无码精品三级在线电影| 亚洲成av人片在线播放无码|