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  4. Recombinant Human 39S ribosomal protein L41, mitochondrial (MRPL41)

Recombinant Human 39S ribosomal protein L41, mitochondrial (MRPL41)

  • 中文名稱：
    人MRPL41重組蛋白
  • 貨號：
    CSB-YP811620HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MRPL41重組蛋白
  • 貨號：
    CSB-EP811620HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MRPL41重組蛋白
  • 貨號：
    CSB-EP811620HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MRPL41重組蛋白
  • 貨號：
    CSB-BP811620HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MRPL41重組蛋白
  • 貨號：
    CSB-MP811620HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MRPL41
  • Uniprot No.：
  • 別名：
    39S ribosomal protein L27 homolog; 39S ribosomal protein L41; 39S ribosomal protein L41 mitochondrial; Bcl-2-interacting mitochondrial ribosomal protein L41; BMRP; Cell proliferation-inducing gene 3 protein; L41mt; mitochondrial; Mitochondrial ribosomal protein L41; MRP L27; MRP-L27 homolog; MRP-L41; MRPL27; mRpL41; PIG3; Proliferation inducing gene 3; RM41_HUMAN; RPML27
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    14-137
  • 氨基酸序列
    GADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
  • 基因功能參考文獻：
    1. Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. PMID: 24160266
    2. Apoptosis-inducing ability of wild-type BMRP is blocked by Bcl-2 through several mechanisms. PMID: 22711503
    3. region of BMRP required for the interaction with Bcl-2 is very relevant for the cell death-inducing activity of the protein PMID: 21253851
    4. BMRP is a mitochondrial ribosomal protein involved in the regulation of cell death by apoptosis, probably affecting pathways mediated by Bcl-2 and caspases. PMID: 15547950
    5. mitochondrial ribosomal protein L41 (MRPL41) is localized in the mitochondria, stabilizes the p53 protein, and enhances its translocation to the mitochondria, thereby inducing apoptosis. PMID: 16024796
    6. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and p27(Kip1) levels under the growth inhibitory conditions. PMID: 16256947

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  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Mitochondrion-specific ribosomal protein mL41 family
  • 組織特異性：
    Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
  • 數據庫鏈接：

    HGNC: 14492

    OMIM: 611846

    KEGG: hsa:64975

    STRING: 9606.ENSP00000360498

    UniGene: Hs.44017



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