在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3), partial

  • 中文名稱:
    人HACD3重組蛋白
  • 貨號:
    CSB-YP878945HU1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人HACD3重組蛋白
  • 貨號:
    CSB-EP878945HU1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人HACD3重組蛋白
  • 貨號:
    CSB-BP878945HU1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人HACD3重組蛋白
  • 貨號:
    CSB-MP878945HU1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    HACD3
  • Uniprot No.:
  • 別名:
    HACD3; BIND1; PTPLAD1; Very-long-chain; 3R-3-hydroxyacyl-CoA dehydratase 3; 3-hydroxyacyl-CoA dehydratase 3; HACD3; Butyrate-induced protein 1; B-ind1; hB-ind1; Protein-tyrosine phosphatase-like A domain-containing protein 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
  • 基因功能參考文獻:
    1. HACD3 (PTPLAD1) is a new candidate gene for type-2 diabetes risk. HACD3 deletion decreases the autophosphorylation of insulin receptor in vitro. HACD3 may regulate the activity of CDK2 and RAB5C.Overexpression of HACD3 inhibits the tyrosine phosphorylation of CDK2 and RAB5C. HACD3 stimulates the physical association of insulin receptor with RAB11A and may regulate the recycling of insulin receptor to the plasma membrane. PMID: 30300385
    2. Our results indicate that PTPLAD1 (HACD3) is in complex with insulin receptor (IR) in rat's liver and in human HEK293 cells. SiRNA-mediated partial knockdown of PTPLAD1 increased level of IR tyrosine phosphorylation and affect IR endocytosis. PTPLAD1 depletion strongly enhanced insulin effect on Glut2 translocation in HEK293 cells similar to the increase in AKT-ser473 phosphorylation. [PTPLAD1] PMID: 25687571
    3. Genes in the erythroid differentiation and cell cycle regulation pathways influence interindividual variation in RBC indices. Our results provide insights into the molecular basis underlying variation in RBC traits. PMID: 22560525
    4. The structure of the B-IND1 gene promoter region was determined. PMID: 16516406
    5. results suggest that hB-ind1 plays a crucial role in HCV RNA replication and the propagation of JFH1 virus through interaction with viral and host proteins PMID: 18160438
    6. These results suggest that an Hsp90-dependent chaperone pathway incorporating hB-ind1 is involved in protein folding in the membranous web for the circumvention of the UPR and that it facilitates HCV replication PMID: 19656872

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Very long-chain fatty acids dehydratase HACD family
  • 組織特異性:
    Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24175

    OMIM: 615940

    KEGG: hsa:51495

    STRING: 9606.ENSP00000261875

    UniGene: Hs.512973



主站蜘蛛池模板: 国产成人精品日本亚洲| 亚洲国产欧美日韩在线人成| 成人a毛片视频免费看| 强奷妇系列中文字幕| 国产人妻久久精品二区三区老狼| 又粗又硬又大又爽免费视频播放| 欧美性xxxx极品少妇| 交换交换乱杂烩系列yy| 人人妻碰人人免费| 国产乱子伦60女人的皮视频| 亚洲 欧美 中文 在线 视频| 国产色无码精品视频国产| 麻豆国产精品va在线观看| 蜜桃av亚洲精品一区二区| 337p日本欧洲亚洲大胆精筑 | 国产美女裸体丝袜喷水视频| 国产明星裸体xxxx视频| 欧美性猛交久久久乱大交小说| 中文字幕无码免费久久| 亚洲最大av无码国产| 丁香婷婷无码不卡在线| 国产拍揄自揄免费观看| 久久久久免费看黄a片app| 少妇人妻偷人精品视蜜桃| 免费人成视频在线观看视频| 亚洲精品久久久久久久久久久捆绑 | 狠狠cao2020高清视频| 高大丰满欧美熟妇hd| 欧美黑人激情性久久| 偷偷色噜狠狠狠狠的777米奇| 曰韩免费无码av一区二区| 国产成人精品福利一区二区三区| 少妇被又大又粗下爽a片| 亚洲男人最新版本天堂| 国产精品成人av在线观看春天 | 欧美高清性色生活片免费观看| 亚洲色无码专区一区| 国产成人无码午夜视频在线播放| 久久久www成人免费无遮挡大片| 图片区小说区激情区偷拍区| 国产无遮挡色视频免费观看性色 |