在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human 3-hydroxyacyl-CoA dehydratase 1 (PTPLA), partial

Recombinant Human 3-hydroxyacyl-CoA dehydratase 1 (PTPLA), partial

  • 中文名稱：
    人HACD1重組蛋白
  • 貨號：
    CSB-YP019018HU1
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HACD1重組蛋白
  • 貨號：
    CSB-EP019018HU1
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HACD1重組蛋白
  • 貨號：
    CSB-EP019018HU1-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HACD1重組蛋白
  • 貨號：
    CSB-BP019018HU1
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HACD1重組蛋白
  • 貨號：
    CSB-MP019018HU1
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HACD1
  • Uniprot No.：
  • 別名：
    HACD1; PTPLA; Very-long-chain; 3R-3-hydroxyacyl-CoA dehydratase 1; 3-hydroxyacyl-CoA dehydratase 1; HACD1; Cementum-attachment protein; CAP; Protein-tyrosine phosphatase-like member A
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.; In tooth development, may play a role in the recruitment and the differentiation of cells that contribute to cementum formation. May also bind hydroxyapatite and regulate its crystal nucleation to form cementum.
  • 基因功能參考文獻：
    1. Labrador retrievers carrying two copies of a unique canine HACD1 loss-of-function allele that recently disseminated worldwide, are all affected by a congenital myopathy, confirming its role in muscle development. PMID: 23071563
    2. Longitudinal analyses in myopathic Labrador retrievers reveal several membrane-associated defects, including ultrastructural triads dysmorphogenesis and mitochondrial mislocalization in Labrador retrievers with deficiencies in the canine HACD1 gene. PMID: 27939133
    3. A loss-of-function mutation in the canine ortholog of HACD1 that was identified by genetic mapping in a French pedigree of Labrador retrievers causes a congenital myopathy named centronuclear myopathy (CNM) in Labrador retrievers. PMID: 15829503
    4. Mutations in HACD1 can result in myopathies in humans; knockout mice lacking Hacd1 develop myopathic phenotypes. Data (including data from studies using knockout mice and cultured cells from knockout mice) suggest that HACD1 and HACD2 exhibit overlapping substrate specificities and thus appear to represent redundant activities in skeletal muscle. PMID: 28784662
    5. These data indicate that HACD1 is necessary for muscle function. PMID: 23933735
    6. PTPLA-CAP expression was limited to cementum cells; promoted gingival fibroblast attachment. PTPLA-CAP is splice variant of PTPLA, and that, in the periodontium, cementum and cementum cells express this variant. PMID: 22067203
    7. HACD1 is 3-hydroxyacyl-CoA dehydratase involved in elongation of very long-chain fatty acids. HACD1 (K64Q) exhibits normal enzyme activity, intracellular localization and interaction with other VLCFA enzymes, with no negative effect on VLCFA elongation PMID: 20724468
    8. PTPLA SNPs show genotypic association with Alzheimer disease. PMID: 19241460

    顯示更多

    收起更多

  • 相關疾病：
    Myopathy, congenital, with fiber-type disproportion (CFTD)
  • 亞細胞定位：
    [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Very long-chain fatty acids dehydratase HACD family
  • 組織特異性：
    Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementob
  • 數據庫鏈接：

    HGNC: 9639

    OMIM: 255310

    KEGG: hsa:9200

    STRING: 9606.ENSP00000355308

    UniGene: Hs.114062



主站蜘蛛池模板： 中文无码日韩欧免费视频| 狂野欧美性猛xxxx乱大交 | 午夜免费啪视频观看视频| 日本成本人片免费网站| 婷婷久久综合九色综合88| 亚洲成av人在线视猫咪| 无码av片在线观看免费| 亚洲肥老太bbw中国熟女| 国内少妇毛片视频| 97夜夜澡人人爽人人喊a| 国产在线无码视频一区二区三区| 欧美综合在线激情专区| 国产肥白大熟妇bbbb视频| 成年午夜性影院免费观看| 一本色道久久综合狠狠躁篇| 国产又色又爽又黄的在线观看| 国产三级a三级三级| 伦人伦xxx国产对白| 国产农村乱人伦精品视频| 夜晚成人18禁区导航网站| 亚洲午夜成人av电影| 国产成人精品a视频一区| 国产精品国产av片国产| 成人乱码一区二区三区av66| 中文字幕无码乱人伦| 日韩成人无码| 欧美xxxxx在线观看| 午夜福利理论片高清在线观看| 边添小泬边狠狠躁视频| 女人和拘做受全程看视频| 国产精品玩偶在线观看| 性高湖久久久久久久久aaaaa| 国产熟女亚洲精品麻豆| 99久久国产综合精品1| 真人二十三式性视频(动)| 日本亲近相奷中文字幕| 国产高清不卡免费视频| 99久久人妻精品免费一区| 日本中国内射bbxx| 国产精品一区二区在线蜜芽tv| 亚洲日韩亚洲另类|