在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human 14 kDa phosphohistidine phosphatase (PHPT1)

Recombinant Human 14 kDa phosphohistidine phosphatase (PHPT1)

  • 中文名稱：
    人PHPT1重組蛋白
  • 貨號：
    CSB-YP868306HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PHPT1重組蛋白
  • 貨號：
    CSB-EP868306HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PHPT1重組蛋白
  • 貨號：
    CSB-EP868306HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PHPT1重組蛋白
  • 貨號：
    CSB-BP868306HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PHPT1重組蛋白
  • 貨號：
    CSB-MP868306HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PHPT1
  • Uniprot No.：
  • 別名：
    14 kDa phosphohistidine phosphatase; CGI 202; HSPC141; Phosphohistidine phosphatase 1; PHP14; PHP14_HUMAN; PHPT1; Protein janus A homolog; Protein janus-A homolog; Sex regulated protein janus a
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-125
  • 氨基酸序列
    AVADLALIP DVDIDSDGVF KYVLIRVHSA PRSGAPAAES KEIVRGYKWA EYHADIYDKV SGDMQKQGCD CECLGGGRIS HQSQDKKIHV YGYSMAYGPA QHAISTEKIK AKYPDYEVTW ANDGY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Exhibits phosphohistidine phosphatase activity.
  • 基因功能參考文獻：
    1. In the process of assay optimization, we discovered that PHPT1 is sensitive to a reducing environment and inhibited by transition-metal ions, with one apparent Cu(II) binding site with IC50 value of 500 +/- 20 muM and two apparent Zn(II) binding sites with IC50 values of 25 +/- 1 and 490 +/- 20 muM PMID: 29630837
    2. High PHPT1 expression is associated with cancer. PMID: 29787434
    3. H2O2 exposure induces selective oxidation of hPHPT1 at Met95, a residue within the substrate binding region. Molecular dynamics simulations suggest that if Met95 oxidation alters hPHPT1 activity, then it will do so by altering the stability of an intermediate state. Mass spectrometry showed that H2O2-induced oxidation does not impact hPHPT1 function negatively. PMID: 27034094
    4. PHPT1 was expressed in the epithelium of proximal tubuli and nuclei of clear-cell renal cell carcinoma tissue samples. PMID: 26537769
    5. PHPT1 can dephosphorylate phospholysine in chemically phosphorylated histone H1 and polylysine PMID: 25574816
    6. The specific degradation of the PHPT1 splice variant indicates that the quality control and the self-guarding of the cellular system works at two levels, first at the RNA level and proteasome level. PMID: 25450458
    7. the histidine phosphatase, protein histidine phosphatase 1, inhibits NDPK-B-activated TRPV5 in inside/out patch experiments. PMID: 24523290
    8. Overexpression of PHP by the use of a plasmid vector, pIRES2-AcGFP1-PHP, induced apoptosis in HUVEC PMID: 21967643
    9. Significantly higher expression levels of PHPT1 protein were found in lung cancer samples than in normal tissues adjacent to lung cancer. PMID: 21163124
    10. these data implicate regulatory roles for PHPT1 in a G protein-sensitive step involved in nutrient-induced insulin secretion PMID: 20501872
    11. These results demonstrate for the first time that PHP14 may be functionally important in lung cancer cell migration and the invasion of lung cancer cells, mediated partly through modulation of actin cytoskeleton rearrangement. PMID: 19344975
    12. Northern blot analysis indicated that the human phosphohistidine phosphatase mRNA was present preferentially in heart and skeletal muscle. PMID: 12383260
    13. In the present work, we have searched for potential active site residues in the human phosphohistidine phosphatase by point mutations of conserved histidine and arginine residues to alanine. PMID: 16219293
    14. Overexpression of PHP results in increased dephosphorylation with concomitant inactivation of ACL, thus finally leading to cell damage. PMID: 18656514
    15. PHPT-1 functions to negatively regulate CD4 T cells PMID: 18796614
    16. Solution structure and catalytic mechanism of human protein histidine phosphatase 1. PMID: 18991813
    17. results suggest that an increased activity of protein histidine phosphatase (PHP) impairs neuron cellular function whereas downregulation of PHP does not PMID: 19138678

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Janus family
  • 組織特異性：
    Expressed abundantly in heart and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 30033

    OMIM: 610167

    KEGG: hsa:29085

    STRING: 9606.ENSP00000247665

    UniGene: Hs.409834



主站蜘蛛池模板： 亚洲国产成人精品无码区二本| 3d动漫精品啪啪一区二区免费| 久久久久久自慰出白浆| 亚洲三区在线观看内射后入| 无码8090精品久久一区| 97夜夜澡人人爽人人| 99久久99久久精品国产片果冻| 狠狠色噜噜狠狠狠狠97首创麻豆| 香港日本三级亚洲三级| 亚洲春色av无码专区在线播放| 最近中文字幕mv在线视频2018| 色妺妺视频网| 亚洲精品一区二区三区蜜臀| 亚洲中文字幕乱码av波多ji| 国产成人无码视频网站在线观看| 国产成人av大片在线观看| 亚洲学生妹高清av| 亚洲一区精品无码| 免费人成视频在线观看视频| 国产午夜亚洲精品久久 | 亚洲中文字幕日产乱码在线| 乱码精品一区二区三区| 五月婷婷久久草丁香| 成人区人妻精品一区二区不卡视频| 欧洲美女黑人粗性暴交视频| 日韩精品亚洲人旧成在线| 无码加勒比一区二区三区四区| 337p日本欧洲亚洲大胆裸体艺术| 7777精品伊人久久久大香线蕉| 国产69精品久久久久乱码免费| 日日天日日夜日日摸| 中文无码av在线亚洲电影| 国产啪精品视频网站| 国产绳艺sm调教室论坛| 亚洲精品无码久久毛片波多野吉衣| 亚洲色大成影网站www永久| 成年女性特黄午夜视频免费看| 国产精品亚洲综合一区在线观看 | 亚洲成av人片在线观看一区二区三区| 亚洲欧洲精品成人久久曰影片| 亚洲国产成人乱码|