在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human 14 kDa phosphohistidine phosphatase (PHPT1)

Recombinant Human 14 kDa phosphohistidine phosphatase (PHPT1)

  • 中文名稱：
    人PHPT1重組蛋白
  • 貨號：
    CSB-BP017942HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PHPT1重組蛋白
  • 貨號：
    CSB-EP017942HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PHPT1重組蛋白
  • 貨號：
    CSB-MP017942HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    PHPT1
  • Uniprot No.：
  • 別名：
    14 kDa phosphohistidine phosphatase; CGI 202; HSPC141; Phosphohistidine phosphatase 1; PHP14; PHP14_HUMAN; PHPT1; Protein janus A homolog; Protein janus-A homolog; Sex regulated protein janus a
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length
  • 表達區(qū)域：
    1-125aa
  • 氨基酸序列
    MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWAEYHADIYDKVSGDMQKQGCDCECLGGGRISHQSQDKKIHVYGYSMAYGPAQHAISTEKIKAKYPDYEVTWANDGY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Exhibits phosphohistidine phosphatase activity.
  • 基因功能參考文獻：
    1. In the process of assay optimization, we discovered that PHPT1 is sensitive to a reducing environment and inhibited by transition-metal ions, with one apparent Cu(II) binding site with IC50 value of 500 +/- 20 muM and two apparent Zn(II) binding sites with IC50 values of 25 +/- 1 and 490 +/- 20 muM PMID: 29630837
    2. High PHPT1 expression is associated with cancer. PMID: 29787434
    3. H2O2 exposure induces selective oxidation of hPHPT1 at Met95, a residue within the substrate binding region. Molecular dynamics simulations suggest that if Met95 oxidation alters hPHPT1 activity, then it will do so by altering the stability of an intermediate state. Mass spectrometry showed that H2O2-induced oxidation does not impact hPHPT1 function negatively. PMID: 27034094
    4. PHPT1 was expressed in the epithelium of proximal tubuli and nuclei of clear-cell renal cell carcinoma tissue samples. PMID: 26537769
    5. PHPT1 can dephosphorylate phospholysine in chemically phosphorylated histone H1 and polylysine PMID: 25574816
    6. The specific degradation of the PHPT1 splice variant indicates that the quality control and the self-guarding of the cellular system works at two levels, first at the RNA level and proteasome level. PMID: 25450458
    7. the histidine phosphatase, protein histidine phosphatase 1, inhibits NDPK-B-activated TRPV5 in inside/out patch experiments. PMID: 24523290
    8. Overexpression of PHP by the use of a plasmid vector, pIRES2-AcGFP1-PHP, induced apoptosis in HUVEC PMID: 21967643
    9. Significantly higher expression levels of PHPT1 protein were found in lung cancer samples than in normal tissues adjacent to lung cancer. PMID: 21163124
    10. these data implicate regulatory roles for PHPT1 in a G protein-sensitive step involved in nutrient-induced insulin secretion PMID: 20501872
    11. These results demonstrate for the first time that PHP14 may be functionally important in lung cancer cell migration and the invasion of lung cancer cells, mediated partly through modulation of actin cytoskeleton rearrangement. PMID: 19344975
    12. Northern blot analysis indicated that the human phosphohistidine phosphatase mRNA was present preferentially in heart and skeletal muscle. PMID: 12383260
    13. In the present work, we have searched for potential active site residues in the human phosphohistidine phosphatase by point mutations of conserved histidine and arginine residues to alanine. PMID: 16219293
    14. Overexpression of PHP results in increased dephosphorylation with concomitant inactivation of ACL, thus finally leading to cell damage. PMID: 18656514
    15. PHPT-1 functions to negatively regulate CD4 T cells PMID: 18796614
    16. Solution structure and catalytic mechanism of human protein histidine phosphatase 1. PMID: 18991813
    17. results suggest that an increased activity of protein histidine phosphatase (PHP) impairs neuron cellular function whereas downregulation of PHP does not PMID: 19138678

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Janus family
  • 組織特異性：
    Expressed abundantly in heart and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30033

    OMIM: 610167

    KEGG: hsa:29085

    STRING: 9606.ENSP00000247665

    UniGene: Hs.409834



主站蜘蛛池模板： 人妻无码久久中文字幕专区 | 人妻少妇被粗大爽9797pw| 日本乱人伦在线观看| 先锋影音xfyy5566男人资源| 国产婷婷亚洲999精品小说| 激情文学小说区另类小说同性| 亚洲午夜av久久久精品影院色戒| 熟妇高潮精品一区二区三区| 国产精品美女久久久久久久久| 亚洲欧美日韩国产成人| 免费观看在线a毛片| 高潮好爽视频在线观看| 日韩欧美亚洲综合久久影院| 欧美特级特黄aaaaaa在线看| 日日摸天天摸爽爽狠狠97| 国产人成网线在线播放va| 欧美亚洲日本国产黑白配| 2020国产成人精品影视| 免费国产裸体美女视频全黄| 亚洲欧洲免费无码| 色天天天综合色天天| 亚洲午夜成人精品无码app| 天天躁夜夜躁狠狠躁2021a2| 337p日本欧洲亚洲大胆张筱雨| 精品乱码一区二区三四区视频| 男女真人国产牲交a做片野外| 久久久久久无码日韩欧美| 97色精品视频在线观看| 国内精品自在自线| 亚洲精品字幕| 亚洲综合久久无码色噜噜赖水| 东京热大乱系列无码| 精品综合久久久久久98| 久久无码人妻丰满熟妇区毛片| 西西人体扒开下部试看120秒 | 国产亚洲曝欧美曝妖精品| 亚洲a∨无码一区二区三区 | 欧美亚洲人成网站在线观看| 久久综合给合久久狠狠97色| 亚洲人成亚洲人成在线观看| www国产亚洲精品久久麻豆|