在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4), partial

  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-YP614882HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-EP614882HU
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-EP614882HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-BP614882HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-MP614882HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; EC 3.1.4.11; Phosphoinositide phospholipase C-beta-4; Phospholipase C-beta-4; PLC-beta-4
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
  • 基因功能參考文獻(xiàn):
    1. Dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review) PMID: 26639088
    2. Novel pathogenic variants in PLCB4 have been found in two of three index patients with typical Auriculocondylar syndrome. PMID: 28328130
    3. Our observations of this case further delineate the phenotype of ACS associated with autosomal recessive PLCB4 loss-of-function mutations, underscoring gastrointestinal dysfunction and severe sleep-related breathing abnormalities as additional features when compared to patients with heterozygous mutations with a presumed dominant negative effect. PMID: 27007857
    4. PLCB4 copy gain and PLCB4 overexpression is associated with gastrointestinal stromal tumors. PMID: 28212550
    5. recurrent mutation in PLCB4 is associated with uveal melanoma. PMID: 26683228
    6. Polymorphism of the PLCB4/B1 genes might be involved in the coronary artery aneurysm pathogenesis of Kawasaki disease. PMID: 26434682
    7. Phospholipase C-beta1 and beta4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells. PMID: 24475116
    8. This study demonistrated by Gene expression profile that PLCB4 upregulaion in fibroblasts of Huntington's disease patients. PMID: 24296361
    9. Auriculocondylar syndrome is caused by PLCB4 mutations inherited not only in an autosomal dominant manner (catalytic domain missense mutations) but also inherited as autosomal recessive (complete loss of function). PMID: 23913798
    10. PLCbeta4 is enriched at the plasma membrane. PMID: 23006664
    11. The phenotypic variability of auriculocondylar syndrome suggests that mutations in this pathway, especially those affecting core signaling molecules such as PLCB4 and GNAI3, should be considered as potential candidates for other ear and jaw malformations. PMID: 22560091
    12. The significant contribution of PSMD3-CSF3 and PLCB4 loci to the regulation of neutrophil count, is demonstrated. PMID: 20172861
    13. Presence of PLCbeta(4) in the heart and in HL-1 cardiomyocytes showing a different species-dependent pattern of expression of the PLCbeta((1-4)) transcripts. PMID: 19856080

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Auriculocondylar syndrome 2 (ARCND2)
  • 組織特異性:
    Preferentially expressed in the retina.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9059

    OMIM: 600810

    KEGG: hsa:5332

    STRING: 9606.ENSP00000334105

    UniGene: Hs.472101



主站蜘蛛池模板: 无码精品久久久天天影视| 国产精品盗摄!偷窥盗摄| 成人免费国产精品视频| 99精品久久久久久久婷婷| 欧美国产综合欧美视频| 夜色约爱网站| 成人影院永久免费观看网址| 四虎成人精品永久在线视频| √天堂8资源中文在线| 女人和拘做爰正片视频| 亚洲欧美日韩国产综合点击进入| 在线观看国产精品av| 国产男女猛烈无遮挡免费视频网站| 精品无码无人网站免费视频 | 日韩精品无码人成视频| 欧美日韩不卡合集视频| 性乌克兰xxxx极品| 麻豆精产一二三产区| 无码熟妇人妻av在线网站| 夜先锋av资源网站| 欧美第一黄网免费网站| 9久9久女女热精品视频在线观看 | 亚洲综合网站精品一区二区| 欧美群交射精内射颜射潮喷| 中文综合在线观| 国产精品美脚玉足脚交| 亚洲精品无码ma在线观看| 精品人妻一区二区三区浪潮在线 | 大伊香蕉精品视频在线直播| 无码成a毛片免费| 成人免费一区二区三区视频| 女性自慰网站免费观看w| 丰满少妇做爰视频爽爽和| 成人无码免费一区二区三区 | 亚洲精品成人网站在线| 韩日午夜在线资源一区二区| 在线天堂www在线国语对白| 精品午夜中文字幕熟女人妻在线| 亚洲精品乱码久久久久久v| 娇小萝被两个黑人用半米长| 大屁股熟女白浆一区二区|