在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4), partial

  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-YP614882HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-EP614882HU
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-EP614882HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-BP614882HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PLCB4重組蛋白
  • 貨號(hào):
    CSB-MP614882HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; EC 3.1.4.11; Phosphoinositide phospholipase C-beta-4; Phospholipase C-beta-4; PLC-beta-4
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
  • 基因功能參考文獻(xiàn):
    1. Dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review) PMID: 26639088
    2. Novel pathogenic variants in PLCB4 have been found in two of three index patients with typical Auriculocondylar syndrome. PMID: 28328130
    3. Our observations of this case further delineate the phenotype of ACS associated with autosomal recessive PLCB4 loss-of-function mutations, underscoring gastrointestinal dysfunction and severe sleep-related breathing abnormalities as additional features when compared to patients with heterozygous mutations with a presumed dominant negative effect. PMID: 27007857
    4. PLCB4 copy gain and PLCB4 overexpression is associated with gastrointestinal stromal tumors. PMID: 28212550
    5. recurrent mutation in PLCB4 is associated with uveal melanoma. PMID: 26683228
    6. Polymorphism of the PLCB4/B1 genes might be involved in the coronary artery aneurysm pathogenesis of Kawasaki disease. PMID: 26434682
    7. Phospholipase C-beta1 and beta4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells. PMID: 24475116
    8. This study demonistrated by Gene expression profile that PLCB4 upregulaion in fibroblasts of Huntington's disease patients. PMID: 24296361
    9. Auriculocondylar syndrome is caused by PLCB4 mutations inherited not only in an autosomal dominant manner (catalytic domain missense mutations) but also inherited as autosomal recessive (complete loss of function). PMID: 23913798
    10. PLCbeta4 is enriched at the plasma membrane. PMID: 23006664
    11. The phenotypic variability of auriculocondylar syndrome suggests that mutations in this pathway, especially those affecting core signaling molecules such as PLCB4 and GNAI3, should be considered as potential candidates for other ear and jaw malformations. PMID: 22560091
    12. The significant contribution of PSMD3-CSF3 and PLCB4 loci to the regulation of neutrophil count, is demonstrated. PMID: 20172861
    13. Presence of PLCbeta(4) in the heart and in HL-1 cardiomyocytes showing a different species-dependent pattern of expression of the PLCbeta((1-4)) transcripts. PMID: 19856080

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Auriculocondylar syndrome 2 (ARCND2)
  • 組織特異性:
    Preferentially expressed in the retina.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9059

    OMIM: 600810

    KEGG: hsa:5332

    STRING: 9606.ENSP00000334105

    UniGene: Hs.472101



主站蜘蛛池模板: 大又大粗又爽又黄少妇毛片免费| 韩国精品视频一区二区在线播放| 成人亚洲欧美一区二区三区| 亚州中文字幕无码中文字幕| 欧美性猛交xxxxx按摩欧美| 暴力强奷在线播放无码| 精品1卡二卡三卡四卡老狼| 波多野结衣av手机在线观看| 中文字幕v亚洲ⅴv天堂| 成人性三级欧美在线观看| 亚洲精品国产一区二区图片 | 野外亲子乱子伦视频丶| 国产成人精品综合久久久| 熟妇人妻久久中文字幕| 国产白浆喷水在线视频| 天天综合网亚在线| 大战丰满无码人妻50p| 欧美牲交a欧美牲交aⅴ免费真 | 国产精品无码一区二区牛牛| 日韩欧美亚洲综合久久影院| 开心久久婷婷综合中文字幕| 亚洲综合在线另类色区奇米| 天堂va欧美va亚洲va好看va| av无码中出一区二区三区| 免费无码国产欧美久久18| 色婷婷美国农夫综合激情亚洲| 精品人妻无码一区二区三区抖音| 国产福利男女xx00视频| 久久天天躁狠狠躁夜夜96流白浆 | 国产成人免费97在线观看| 久久免费视频精品在线| 亚洲中文在线精品国产| 18禁止看的免费污网站| 无码人妻精品一区二区三区东京热 | 成在人线av无码免费高潮水老板| 国产未成女一区二区| 色插图午夜影院| 女人被弄到高潮的免费视频| 亚洲人成电影网站色迅雷| 亚洲欧美国产va在线播放| 熟女内射v888av|