在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Heteroscodra maculata Delta-theraphotoxin-Hm1a

  • 中文名稱:
    Recombinant Heteroscodra maculata Delta-theraphotoxin-Hm1a
  • 貨號:
    CSB-YP351577HGU
  • 規格:
    ¥3612
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    N/A
  • Uniprot No.:
  • 別名:
    ; Delta-theraphotoxin-Hm1a; Delta-TRTX-Hm1a; Heteroscodratoxin-1; HmTx1; Kappa-theraphotoxin-Hm1a; Kappa-TRTX-Hm1a
  • 種屬:
    Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)
  • 蛋白長度:
    Full Length
  • 來源:
    Yeast
  • 分子量:
    4.0kDa
  • 表達區域:
    1-35aa
  • 氨基酸序列
    ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Gating-modifier toxin that potently inhibits inactivation of the mammalian Nav1.1/SCN1A sodium channel (EC(50)=38 nM). Also moderately inhibits inactivation of Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM) when the channels are expressed in oocytes without the beta-1 auxiliary subunit. Does not inhibit inactivation of Nav1.2/SCN2A when the channel is coexpressed with the beta-1 auxiliary subunit. When tested on Nav1.1/SCN1A channel, it enhances peak current amplitude and potently delays channel inactivation in a dose-dependent manner, leading to a large sustained current. It has no effect on the voltage-dependence of steady-state activation, and induces a depolarizing shift in the voltage dependence of inactivation. In addition, it does not modify the recovery from fast inactivation in Nav1.1/SCN1A. The binding affinity and subtype selectivity of the toxin towards Nav1.1/SCN1A channel is determined by residues within both the S1-S2 and S3-S4 loops of the domain IV voltage sensor of the channel. This toxin also weakly inhibits several subtypes of voltage-gated potassium channels. It moderately blocks Kv2.1/KCNB1 (23% inhibition at 100 nM), Kv2.2/KCNB2 (19.7% at 100 nM and 51% at 300 nM), Kv4.1/KCND1 (IC(50)=280 nM), Kv4.2/KCND2 (39% at 300 nM) and Kv4.3/KCND3 (43% at 300 nM). In vivo, intracerebroventricular injection into mice elicits convulsions, spasms, tremors and rapid death. When injected into mouse hindpaw, the toxin elicits an immediate and robust response to pain. However, intraplantar injection of toxin does not cause neurogenic inflammation or alter sensitivity to heat, indicative of a modality-specific effect on mechanosensitive neurons. In Dravet syndrome mice model, intracerebroventricular infusion of this peptide rescues mice from seizures and premature death.
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Huwentoxin-1 family, HaTx subfamily
  • 組織特異性:
    Expressed by the venom gland.


主站蜘蛛池模板: 国产成人久久综合第一区| 九色精品国产成人综合网站| 天堂www中文资源| 亚洲另类激情综合偷自拍图| 国产激情精品一区二区三区| 高潮喷吹一区二区在线观看 | 又黄又爽又色视频免费 | 西西人体大胆午夜视频| 9l国产精品久久久久尤物| 国产精品一区波多野结衣| 波多野无码黑人在线播放| 中文无码日韩欧| 亚洲国产成人精品无码区99| 久久精品无码一区二区app| 邪恶肉肉全彩色无遮盖| 免费观看全黄做爰大片国产| 国产sm主人调教女m视频| 无码超乳爆乳中文字幕久久| 国产高清在线精品一区二区三区| 成人性生交大片免费看中文| 欧美成人免费全部| 中文字幕久精品免费视频| 精品久久久久香蕉网| 亚洲欧美日韩综合一区二区| 一本大道一卡2卡三卡4卡国产| 亚洲中文综合网五月俺也去| 窝窝午夜色视频国产精品破 | 国产在线不卡视频免费视频| 99久久国产精品免费高潮| 97无码免费人妻超级碰碰碰碰| 永久免费无码av网站在线观看| 好男人社区资源| 国产日产欧产精品精品免费| 久久久久国色av免费观看| 性生交大片免费看| 青青国产揄拍视频| 婷婷色五月开心五月| 无码粉嫩虎白一线天在线观看| 欧美变态另类xxxx| 亚洲中文无码mv| 欧美伊人久久大香线蕉综合|