在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Heteroscodra maculata Delta-theraphotoxin-Hm1a

In Stock
  • 中文名稱:
    Recombinant Heteroscodra maculata Delta-theraphotoxin-Hm1a
  • 貨號:
    CSB-EP351577HGU
  • 規(guī)格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    N/A
  • Uniprot No.:
  • 別名:
    ; Delta-theraphotoxin-Hm1a; Delta-TRTX-Hm1a; Heteroscodratoxin-1; HmTx1; Kappa-theraphotoxin-Hm1a; Kappa-TRTX-Hm1a
  • 種屬:
    Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    24.0kDa
  • 表達區(qū)域:
    1-35aa
  • 氨基酸序列
    ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Gating-modifier toxin that potently inhibits inactivation of the mammalian Nav1.1/SCN1A sodium channel (EC(50)=38 nM). Also moderately inhibits inactivation of Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM) when the channels are expressed in oocytes without the beta-1 auxiliary subunit. Does not inhibit inactivation of Nav1.2/SCN2A when the channel is coexpressed with the beta-1 auxiliary subunit. When tested on Nav1.1/SCN1A channel, it enhances peak current amplitude and potently delays channel inactivation in a dose-dependent manner, leading to a large sustained current. It has no effect on the voltage-dependence of steady-state activation, and induces a depolarizing shift in the voltage dependence of inactivation. In addition, it does not modify the recovery from fast inactivation in Nav1.1/SCN1A. The binding affinity and subtype selectivity of the toxin towards Nav1.1/SCN1A channel is determined by residues within both the S1-S2 and S3-S4 loops of the domain IV voltage sensor of the channel. This toxin also weakly inhibits several subtypes of voltage-gated potassium channels. It moderately blocks Kv2.1/KCNB1 (23% inhibition at 100 nM), Kv2.2/KCNB2 (19.7% at 100 nM and 51% at 300 nM), Kv4.1/KCND1 (IC(50)=280 nM), Kv4.2/KCND2 (39% at 300 nM) and Kv4.3/KCND3 (43% at 300 nM). In vivo, intracerebroventricular injection into mice elicits convulsions, spasms, tremors and rapid death. When injected into mouse hindpaw, the toxin elicits an immediate and robust response to pain. However, intraplantar injection of toxin does not cause neurogenic inflammation or alter sensitivity to heat, indicative of a modality-specific effect on mechanosensitive neurons. In Dravet syndrome mice model, intracerebroventricular infusion of this peptide rescues mice from seizures and premature death.
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Huwentoxin-1 family, HaTx subfamily
  • 組織特異性:
    Expressed by the venom gland.


主站蜘蛛池模板: 伊人色综合九久久天天蜜桃| 国产精品无码综合区| 午夜无码福利伦利理免| 国产99在线 | 中国| 国产三级在线观看完整版| 欧美一区二区三区| 各处沟厕大尺度偷拍女厕嘘嘘| 纯肉无遮挡无码日本动漫| 伊人久久大香线蕉综合bd高清| 加勒比东京热无码一区| 成熟女人毛片www免费版在线| 九九精品成人免费国产片| 丰满人妻被公侵犯完整版| 日日摸日日碰夜夜爽亚洲| 亚洲色偷偷偷综合网| 69久久国产露脸精品国产| 亚洲 欧美 自拍 美腿 卡通| 免费国产午夜视频在线| 日本免费一区二区三区中文字幕 | 中文字幕婷婷日韩欧美亚洲| 2021麻豆剧传媒一二三区| 人妻熟女一区二区aⅴ千叶宁真| 国产精品女同一区二区| 亚洲日韩日本中文在线| 884aa四虎影成人精品| 久久久久久九九99精品| 亚洲偷自拍国综合色帝国| 一区二区三区毛aaaa片特级| 国产农村老太xxxxhdxx| 精品国产精品久久一区免费式| 樱花草在线社区www日本影院| 亚洲欧美日韩综合俺去了| 欧美肥胖老妇bbw| 香蕉精品亚洲二区在线观看| 久久久久影院美女国产主播| 国产精品福利一区二区| 久久久免费精品re6| 丁香五月亚洲中文字幕| 亚洲欧美综合在线天堂| 久久久久久毛片免费播放| 18禁男女污污污午夜网站免费暖暖|