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  4. Recombinant Epstein-Barr virus Envelope glycoprotein L (GL)

Recombinant Epstein-Barr virus Envelope glycoprotein L (GL)

  • 中文名稱：
    Recombinant Epstein-Barr virus Envelope glycoprotein L(GL)
  • 貨號：
    CSB-YP625354EEZ
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Epstein-Barr virus Envelope glycoprotein L(GL)
  • 貨號：
    CSB-EP625354EEZ
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Epstein-Barr virus Envelope glycoprotein L(GL)
  • 貨號：
    CSB-EP625354EEZ-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Epstein-Barr virus Envelope glycoprotein L(GL)
  • 貨號：
    CSB-BP625354EEZ
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Epstein-Barr virus Envelope glycoprotein L(GL)
  • 貨號：
    CSB-MP625354EEZ
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    gL
  • Uniprot No.：
  • 別名：
    gL; BKRF2Envelope glycoprotein L; gL
  • 種屬：
    Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    23-137
  • 氨基酸序列
    NWAYPCCH VTQLRAQHLL ALENISDIYL VSNQTCDGFS LASLNSPKNG SNQLVISRCA NGLNVVSFFI SILKRSSSAL TGHLRELLTT LETLYGSFSV EDLFGANLNR YAWHRGG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. The heterodimer gH/gL targets also host EPHA2 to promote viral entry.
  • 基因功能參考文獻：
    1. present findings highlight an important role of gL in the kinetics of gB-mediated epithelial cell fusion, adding to previous findings indicating a direct interaction between gL and gB in EBV membrane fusion PMID: 28956769
    2. It is suggested that the Gibbs free energy released as a result of the high-affinity interaction of gHgL with an integrin contributes to the activation energy required to cause the refolding of gB from a prefusion to a postfusion conformation. PMID: 25142593
    3. The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion. PMID: 23325693
    4. investigated whether soluble EBV gH/gL (sgH/gL) functions in fusion; overall, results suggest that domain IV may be required for proper folding and the transmembrane domain and cytoplasmic tail of EBV gH/gL are required for the most efficient fusion PMID: 23200314
    5. The authors report that integrin alphavbeta5 can also bind to Epstein-Barr virus gHgL and trigger fusion. PMID: 21957301

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  • 亞細胞定位：
    Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network.
  • 蛋白家族：
    Herpesviridae glycoprotein L family
  • 數據庫鏈接：

    KEGG: vg:5176156



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