在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Epstein-Barr virus Deneddylase BPLF1 (BPLF1), partial

In Stock
  • 貨號:
    CSB-EP365871EFA
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    BPLF1
  • Uniprot No.:
  • 種屬:
    Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    41.9 kDa
  • 表達區域:
    1-320aa
  • 氨基酸序列
    MSNGDWGQSQRTRGTGPVRGIRTMDVNAPGGGSGGSALRILGTASCNQAHCKFGRFAGIQCVSNCVLYLVKSFLAGRPLTSRPELDEVLDEGARLDALMRQSGILKGHEMAQLTDVPSSVVLRGGGRVHIYRSAEIFGLVLFPAQIANSAVVQSLAEVLHGSYNGVAQFILYICDIYAGAIIIETDGSFYLFDPHCQKDAAPGTPAHVRVSTYAHDILQYVGAPGAQYTCVHLYFLPEAFETEDPRIFMLEHYGVYDFYEANGSGFDLVGPELVSSDGEAAGTPGADSSPPVMLPFERRIIPYNLRPLPSRSFTSDSFPA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.
  • 基因功能參考文獻:
    1. This work evaluates how EBV's BPLF1 protein and its conserved deubiquitinating activity regulate the cellular DNA repair enzyme polymerase eta and recruit it to potential sites of viral damage and replication, resulting in enhanced production of infectious virus. PMID: 28724765
    2. The results implicate BPLF1 in human B-cell transformation and tumor formation in humanized mice. PMID: 26489865
    3. we show that the conserved herpesvirus large tegument protein BPLF1, acts as a functional ubiquitin ligase and deubiquitinase in EBV-producing B cells PMID: 24586164
    4. The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity. PMID: 24672041
    5. The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1. PMID: 22474075
    6. BPLF1 deubiquitinates TRAF6 to inhibit NF-kappaB signal transduction, leading to promotion of viral lytic DNA replication. PMID: 23365429

    顯示更多

    收起更多

  • 亞細胞定位:
    Virion tegument. Host cytoplasm. Host nucleus.
  • 蛋白家族:
    Herpesviridae large tegument protein family
  • 數據庫鏈接:

    KEGG: vg:3783726



主站蜘蛛池模板: 无码国内精品久久人妻 | 亚洲线精品一区二区三八戒| 欧美国产日韩a欧美在线观看| 伊人久久大香线蕉av五月天| 天天摸天天做天天爽水多| 少妇太爽了在线观看免费视频| 色情久久久av熟女人妻网站| 中文字幕卡二和卡三的视频 | 亚洲18禁私人影院| 天天av天天爽无码中文| 97影院理论午夜伦不卡| 狠狠色丁香五月综合缴情婷婷五月 | 成在人线av无码免观看| 春药高潮抽搐流白浆在线观看| 韩国无码av片在线观看网站| 精品国产天线2019| 国产无套内射普通话对白| 亚洲va中文字幕无码久久| 少妇精品偷拍高潮少妇小说| 成人午夜精品无码一区二区三区| 1000部拍拍拍18勿入免费视频下载| 国产精品久免费的黄网站| 又湿又黄裸乳漫画无遮挡网站| 2021在线不卡国产麻豆| 69综合精品国产二区无码| 国产精品午夜福利麻豆| 一本色道久久综合狠狠躁篇| 精品久久久久久中文字幕202| 丰满人妻被黑人猛烈进入| 99久久精品国产一区二区三区| 久久综合97丁香色香蕉| 国产成人午夜无码电影在线观看 | 国产美女口爆吞精普通话| 日日摸日日碰夜夜爽亚洲 | 欧美性猛交xxxx免费视频软件| 国产天堂久久天堂av色综合| 人妻av无码系列一区二区三区| 成人亚洲性情网站www在线观看 | 中国国产野外1级毛片视频| 国产又爽又黄又刺激的视频| 国产精品无码天天爽视频|