在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Drosophila melanogaster Thioredoxin reductase 1, mitochondrial (Trxr1), partial

In Stock
  • 中文名稱:
    黑腹果蠅Trxr1重組蛋白
  • 貨號:
    CSB-EP310089DLU
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    Trxr1
  • Uniprot No.:
  • 別名:
    TrxR-1
  • 種屬:
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    58.9 kDa
  • 表達(dá)區(qū)域:
    111-588aa
  • 氨基酸序列
    GSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRSGLD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.
  • 基因功能參考文獻(xiàn):
    1. Overexpression of mitochondrial TXNRD2 in Drosophila melanogaster extended median lifespan in female flies with a small lifespan extension in males; in contrast, overexpression of the cytosolic form, TXNRD1, did not produce a lifespan extension. PMID: 28474396
    2. Molecular orbital calculations suggested that the C-terminal hexapeptide Pro-Ala-Ser-Cys-Cys-Ser-OH functions as a redox center that alleviates the necessity for selenium in Dm-TrxR. PMID: 21389620
    3. mitochondrial and cytoplasmic variants are both essential for viability PMID: 11796729
    4. analysis of the mechanism of high Mr thioredoxin reductase from Drosophila melanogaster PMID: 12816954
    5. changing of His106 to asparagine, glutamine, and phenylalanine in various C-terminal mutants of Drosophila melanogaster thioredoxin reductase drops catalytic activity without change in pH profile PMID: 15670839
    6. X-ray crystal structure of thioredoxin reductase at 2.4 A resolution; demonstrated that tetrapeptides equivalent to the oxidized C-terminal active sites of both mouse mitochondrial TR (mTR3) and DmTR are substrates for the truncated forms of both enzymes PMID: 17385893
    7. redox potentials provide direct evidence for proposed catalytic mechanism of DmTrxR, & cast new light on essential role of DmTrx system in cycling GSSG/GSH & maintaining intracellular redox homeostasis in D. melanogaster without glutathione reductase. PMID: 17550271
    8. rates of steps in both the reductive and the oxidative half-reactions are markedly diminished in H464'Q thioredoxin reductase as compared to those of wild-type enzyme, indicating that His-464' is involved in both half-reactions PMID: 18211101
    9. the role of Glu-469' in catalysis by DmTrxR PMID: 18991392

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform B]: Mitochondrion.; [Isoform A]: Cytoplasm.
  • 蛋白家族:
    Class-I pyridine nucleotide-disulfide oxidoreductase family
  • 組織特異性:
    During embryogenesis, expression is seen in germ cell progenitors, developing midgut, hindgut and proventriculus.
  • 數(shù)據(jù)庫鏈接:

    KEGG: dme:Dmel_CG2151

    STRING: 7227.FBpp0071116

    UniGene: Dm.20991



主站蜘蛛池模板: 人妻少妇乱孑伦无码专区蜜柚| 日本japanese丰满白浆| 免费的黄网站在线观看| 精品久久久久久久久久久国产字幕| 国产精品亚洲综合久久系列| 五十路熟妇强烈无码| 色婷婷综合久色aⅴ五区最新| 天天爽天天爽夜夜爽毛片| 国产69囗曝吞精在线视频| 欧美人与动性行为视频| 久久无码精品一区二区三区| 9l国产精品久久久久尤物| 正在播放国产真实哭都没用| 中文字幕+乱码+中文字幕一区| 丰满亚洲大尺度无码无码专线| 在线天堂中文在线资源网| 亚洲系列一区中文字幕| 国产果冻豆传媒麻婆精东| 丰满少妇人妻无码专区| 97视频在线观看播放| 久久婷婷大香萑太香蕉av人| 久久经精品久久精品免费观看| 可以直接免费观看的av网站| 性色a∨精品高清在线观看| 国内精品久久久久久久影院| а天堂中文在线官网在线| 亚洲精品成人无限看| 国产无遮挡又爽又黄大胸免费| 在线a亚洲v天堂网2018| 久久婷婷人人澡人人爽人人爱| 波多野42部无码喷潮在线| 国产无遮挡又黄又爽奶头| 国产免费牲交视频| 国产又粗又猛又大爽老大爷| 国产成人无码精品一区二区三区| 国产乱人伦偷精精品视频| 久久大香香蕉国产| 色欲天天网站欧美成人福利网| 亚洲色欲色欲综合网站| 97久久精品亚洲中文字幕无码| 成人亚洲欧美一区二区三区|