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  4. Recombinant Drosophila melanogaster Signal transducer and transcription activator (Stat92E), partial

Recombinant Drosophila melanogaster Signal transducer and transcription activator (Stat92E), partial

  • 中文名稱：
    黑腹果蠅Stat92E重組蛋白
  • 貨號：
    CSB-YP638755DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Stat92E重組蛋白
  • 貨號：
    CSB-EP638755DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Stat92E重組蛋白
  • 貨號：
    CSB-EP638755DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Stat92E重組蛋白
  • 貨號：
    CSB-BP638755DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Stat92E重組蛋白
  • 貨號：
    CSB-MP638755DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Stat92E
  • Uniprot No.：
  • 別名：
    Stat92E; MARE; mrL; Stat; CG4257; Signal transducer and transcription activator; d-STAT; Protein marelle
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development.
  • 基因功能參考文獻：
    1. critical in vivo regulator of glial responsiveness to axonal injury PMID: 25369313
    2. educed Wingless (Wg) signaling dominantly inhibits Stat92E activity in the hinge PMID: 23978534
    3. stat92E activity is regulated along the proximodistal axis to pattern this axis and control the relative expansion of the pouch, hinge, and notum in developing Drosophila PMID: 23499656
    4. modulating STAT activity levels regulates competitor status PMID: 22992954
    5. Loss of Stat92E in the early embryo down-regulates early zygotic genes important for pattern formation. PMID: 21637778
    6. sumoylation has a repressive role in the regulation of the JAK/STAT pathway PMID: 20616536
    7. Characterization of Stat92E that promotes tunmorigenesis in Drosophila is reported. PMID: 20501334
    8. An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. PMID: 20171201
    9. signal activates the JAK/STAT92E pathway in neighboring epithelial cells, causing them to become invasive. PMID: 11779460
    10. stat92E is necessary for the early differentiation of follicle cells during Drosophila oogenesis PMID: 11846485
    11. Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. PMID: 12231627
    12. Taken together with the appearance of STAT92E in a gradient in the hindgut epithelium, these results support a model in which an anteroposterior gradient of ligand results in a gradient of activated STAT. PMID: 12441298
    13. stat92E mutants are defective in tracheal formation, hindgut elongation, and nervous system development PMID: 14654218
    14. A genetic analysis was made of Stat92E to larval hemocyte concentration and the egg encapsulation response. PMID: 15082553
    15. direct evidence that the JAK/STAT pathway mediates a key signal from the somatic gonad that regulates male germline sexual development PMID: 16049490
    16. STAT signalling controls cell motility during germ cell migration. PMID: 16477645
    17. Study shows that although STAT directly regulates Sxl establishment promoter (SxlPe), it is dispensable for promoter activation, instead, JAK/STAT is needed to maintain high-level SxlPe expression in order to ensure Sxl autoregulation in XX embryos. PMID: 17363251
    18. Study examines the natural DNA-binding sites of the single Drosophila Stat and show that Stat92E is able to bind to and activate target gene expression through palindromic sites separated by spacers of both three or four nucleotides. PMID: 18802449
    19. Genome-wide expression profiling on eye discs in which Stat92E is hyperactivated, revealed 584 differentially regulated genes. PMID: 19504457
    20. STAT92E activity is restricted to hub-proximal germ cells. STAT92E activation appears to be necessary to promote male germline stem cell establishment & for onset of self-renewing GSC divisions. PMID: 19643104
    21. JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila. PMID: 15686618

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Transcription factor STAT family
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG4257

    STRING: 7227.FBpp0088489

    UniGene: Dm.2627



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