在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Drosophila melanogaster Protein patched (ptc), partial

  • 中文名稱:
    黑腹果蠅ptc重組蛋白
  • 貨號:
    CSB-YP322442DLU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    黑腹果蠅ptc重組蛋白
  • 貨號:
    CSB-EP322442DLU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    黑腹果蠅ptc重組蛋白
  • 貨號:
    CSB-EP322442DLU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    黑腹果蠅ptc重組蛋白
  • 貨號:
    CSB-BP322442DLU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    黑腹果蠅ptc重組蛋白
  • 貨號:
    CSB-MP322442DLU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ptc
  • Uniprot No.:
  • 別名:
    ptc; CG2411; Protein patched; Hedgehog receptor
  • 種屬:
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).
  • 基因功能參考文獻:
    1. a mutation of the PTC PY motif, which mediates binding of C2-WW-HECT family members, inhibits its internalization but not its autonomous and non-autonomous signalling activities. the two related UB-C2-WW-HECT ligases NEDD4 and SU(DX) regulate PTC trafficking and finely tune its accumulation through partially redundant but distinct functions PMID: 26446620
    2. Kto-Skd affects the A/P-axial development of the whole wing disc. Kto can interact with Cubitus interruptus (Ci), bind to the Ci-binding region on ptc promoter, which are both regulated by Hh signals to down-regulate ptc expression. PMID: 24962581
    3. in vivo study demonstrates that the PI3K-cIII complex is essential for downregulating Patched via the endosomal-lysosomal pathway to execute axon pruning PMID: 25458013
    4. Self-induced patched receptor down-regulation modulates cell sensitivity to the hedgehog morphogen gradient. PMID: 20736483
    5. hedgehog (Hh) promotes the entry of Sxl into the nucleus in the wing disc; in the anterior compartment, Patched (Ptc) is required for this effect, revealing Ptc as a positive effector of Hh PMID: 14597576
    6. finding suggests that dominant-negative function can be conferred by interruption of different aspects of Patched protein behaviour PMID: 15042702
    7. Patched (Ptc), the Hh receptor, restrains both Hedgehog spreading and Hedgehog signaling. PMID: 15102702
    8. results support a model in which the ratio of bound to unbound Ptc molecules determines the cellular response to Hedgehog PMID: 15300262
    9. the Hh/Ptc complex is internalized in the Rab7-enriched lysosomal compartment in a Ptc-dependent manner without the co-receptor Smoothened (Smo). PMID: 15572139
    10. The role of Patched (Ptc) in regulating the guidance of medial tract, one of the longitudinal tracts in the nerve cord, is investigated. PMID: 15754211
    11. Ptc, as well as truncated Ptc deleted of its C-terminal domain, forms a stable trimer. This observation is consistent with the proposal that Ptc is structurally similar to trimeric transporters. PMID: 16980583
    12. lipophorins internalization does not play a major role in Hedgehog (Hh) signal transduction but does in Hh gradient formation PMID: 18198278

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Patched family
  • 數據庫鏈接:


主站蜘蛛池模板: 四虎国产精品永久地址49| 亚洲国产成人久久综合下载| 亚洲人成网站在线无码| 四虎免费最新在线永久4hu| 成年无码动漫av片在线尤物网站| 蜜臀av无码精品人妻色欲| 99久久国产宗和精品1上映| 国产破外女出血视频| 野花社区www视频最新资源| 中文精品久久久久人妻不卡| 亚洲精品tv久久久久久久久久 | 中文字幕中文有码在线| 久久国产高潮流白浆免费观看| 熟女人妻水多爽中文字幕| 人妻被按摩师玩弄到潮喷| 国产在线码观看超清无码视频| 真实国产熟睡乱子伦视频| 国产精品无码人妻一区二区在线| 女女同性av片在线观看免费| 国产超碰人人做人人爽av大片| 九九精品无码专区免费| 久久久久欧美精品| 亚洲综合在线视频自拍| 无码一区二区三区av在线播放| 少妇被爽到高潮动态图| 亚洲黑人巨大videos| 亚洲精品第一国产综合国服瑶| 五月天激情国产综合婷婷婷| 久久欧美国产伦子伦精品| 久久大蕉香蕉免费| 久久久久av无码免费网| 中文字幕无线码| 亚洲高清无码加勒比| 免费国产午夜视频在线| 丰满人妻一区二区三区视频53| 亚洲综合一区二区三区四区五区| 无码免费中文字幕视频| 男女猛烈xx00免费视频试看| 亚洲中文色欧另类欧美| 久久激情五月丁香伊人| 亚洲人成无码网站久久99热国产|