在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Drosophila melanogaster Protein patched (ptc), partial

Recombinant Drosophila melanogaster Protein patched (ptc), partial

  • 中文名稱：
    黑腹果蠅ptc重組蛋白
  • 貨號：
    CSB-YP322442DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅ptc重組蛋白
  • 貨號：
    CSB-EP322442DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅ptc重組蛋白
  • 貨號：
    CSB-EP322442DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅ptc重組蛋白
  • 貨號：
    CSB-BP322442DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅ptc重組蛋白
  • 貨號：
    CSB-MP322442DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ptc
  • Uniprot No.：
  • 別名：
    ptc; CG2411; Protein patched; Hedgehog receptor
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).
  • 基因功能參考文獻：
    1. a mutation of the PTC PY motif, which mediates binding of C2-WW-HECT family members, inhibits its internalization but not its autonomous and non-autonomous signalling activities. the two related UB-C2-WW-HECT ligases NEDD4 and SU(DX) regulate PTC trafficking and finely tune its accumulation through partially redundant but distinct functions PMID: 26446620
    2. Kto-Skd affects the A/P-axial development of the whole wing disc. Kto can interact with Cubitus interruptus (Ci), bind to the Ci-binding region on ptc promoter, which are both regulated by Hh signals to down-regulate ptc expression. PMID: 24962581
    3. in vivo study demonstrates that the PI3K-cIII complex is essential for downregulating Patched via the endosomal-lysosomal pathway to execute axon pruning PMID: 25458013
    4. Self-induced patched receptor down-regulation modulates cell sensitivity to the hedgehog morphogen gradient. PMID: 20736483
    5. hedgehog (Hh) promotes the entry of Sxl into the nucleus in the wing disc; in the anterior compartment, Patched (Ptc) is required for this effect, revealing Ptc as a positive effector of Hh PMID: 14597576
    6. finding suggests that dominant-negative function can be conferred by interruption of different aspects of Patched protein behaviour PMID: 15042702
    7. Patched (Ptc), the Hh receptor, restrains both Hedgehog spreading and Hedgehog signaling. PMID: 15102702
    8. results support a model in which the ratio of bound to unbound Ptc molecules determines the cellular response to Hedgehog PMID: 15300262
    9. the Hh/Ptc complex is internalized in the Rab7-enriched lysosomal compartment in a Ptc-dependent manner without the co-receptor Smoothened (Smo). PMID: 15572139
    10. The role of Patched (Ptc) in regulating the guidance of medial tract, one of the longitudinal tracts in the nerve cord, is investigated. PMID: 15754211
    11. Ptc, as well as truncated Ptc deleted of its C-terminal domain, forms a stable trimer. This observation is consistent with the proposal that Ptc is structurally similar to trimeric transporters. PMID: 16980583
    12. lipophorins internalization does not play a major role in Hedgehog (Hh) signal transduction but does in Hh gradient formation PMID: 18198278

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Patched family
  • 數據庫鏈接：


主站蜘蛛池模板： 成人无码a∨电影免费| 欧美片内射欧美美美妇| 日韩免费无码视频一区二区三区| 精品乱码一区二区三四五区| 欧美xxxxx高潮喷水| 欧美gv在线观看| 亚洲欧美综合精品成人网| 国产 制服丝袜 动漫在线| 国产成人精品一区二区在线小狼| 美女张开腿让人桶| 日本一卡2卡三卡4卡免费网站| 中文在线天堂а√在线| 国产人妻一区二区三区久| 国产成人精品成人a在线观看| 亚洲人成手机电影网站| 国产3p露脸普通话对白| 国产精品久久久久久无码| 国产精品亚洲综合久久系列| 国产成人麻豆亚洲综合精品| 久久精品无码精品免费专区| 女人张开腿让男人桶爽| 大香伊蕉日本一区二区| 无码播放一区二区三区| 九九热在线视频观看这里只有精品 | 成人无码av一区二区三区| 伊人色合天天久久综合网| 免费无码毛片一区二三区| 国产白丝无码免费视频| 国产亚洲精品第一综合另类| 欧美 变态 另类 人妖| 特黄 做受又硬又粗又大视频| 午夜香蕉成视频人网站| 内射精品无码中文字幕| 米奇影视第四色| 一色屋精品视频在线观看免费| 国产午夜精品久久久久免费视| 春色校园综合人妻av| av无码天堂一区二区三区| 在线精品自偷自拍无码中文| 色播久久人人爽人人爽人人片av| 中文字幕丰满伦子无码|