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  4. Recombinant Drosophila melanogaster Protein lap4 (scrib), partial

Recombinant Drosophila melanogaster Protein lap4 (scrib), partial

  • 中文名稱：
    黑腹果蠅scrib重組蛋白
  • 貨號：
    CSB-YP759067DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅scrib重組蛋白
  • 貨號：
    CSB-EP759067DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅scrib重組蛋白
  • 貨號：
    CSB-EP759067DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅scrib重組蛋白
  • 貨號：
    CSB-BP759067DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅scrib重組蛋白
  • 貨號：
    CSB-MP759067DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    scrib; smi; vart; CG5462; Protein lap4; Protein scribble; Protein smell-impaired
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior.
  • 基因功能參考文獻：
    1. the simultaneous loss of the asymmetric cell division regulators Canoe (afadin in mammals) and Scribble in neuroblast clones leads to tumor-like overgrowth through both a severe disruption of the asymmetric cell division process and canoe loss-mediated Ras-PI3K-Akt activation PMID: 28619817
    2. the effects of loss of scrib and the modification of these effects via cooperative interactions that enhance the overall tumorigenic potential of scrib deficient cells, is reported. PMID: 27327956
    3. Knocking down scribble expression in either Mushroom body neurons or Dopaminergic neurons impairs normal memory loss. PMID: 27263975
    4. Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo. PMID: 25005475
    5. Drosophila scrib acts downstream of the Fat (Ft) receptor, and requires Hippo signaling for its growth regulatory functions. PMID: 23144804
    6. Loss of Scrib promotes Yorkie/Scalloped-dependent epithelial tissue overgrowth, and this is also important for driving cooperative tumor overgrowth with oncogenic Ras-Raf signaling. PMID: 21955824
    7. Data show that mutations causing the loss of Salvador (Sav) or Scribble (Scrib) or activation of Ras transform normal stem cells into cancer stem cells through a multistep process in the adult Drosophila Malpighian tubules. PMID: 20432470
    8. These results demonstrate distinct aPKC and JNK-dependent pathways through which loss of Scrib promotes tumourigenesis in Drosophila. PMID: 19778415
    9. Scrib is essential for olfactory behavior in D. melanogaster. PMID: 12930751

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  • 亞細胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Note=Localized to epithelial septate junction at the boundary of the apical and basolateral cell surfaces.
  • 蛋白家族：
    LAP (LRR and PDZ) protein family
  • 組織特異性：
    During germ band extension, expression of isoform A occurs predominantly in neuroblasts derived from the neuro-ectoderm and later is restricted to CNS neurons and pole cells. Isoform C is strongly expressed in PNS and a subset of CNS neurons. In the adult
  • 數據庫鏈接：


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