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  4. Recombinant Drosophila melanogaster Protein crumbs (crb), partial

Recombinant Drosophila melanogaster Protein crumbs (crb), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Protein crumbs(crb) ,partial
  • 貨號：
    CSB-YP318706DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Protein crumbs(crb) ,partial
  • 貨號：
    CSB-EP318706DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Protein crumbs(crb) ,partial
  • 貨號：
    CSB-EP318706DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Protein crumbs(crb) ,partial
  • 貨號：
    CSB-BP318706DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Protein crumbs(crb) ,partial
  • 貨號：
    CSB-MP318706DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    crb
  • Uniprot No.：
  • 別名：
    crb; CG6383Protein crumbs; 95F
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a central role in cell polarity establishment, and contributes to the organization of zonula adherens, epithelial morphogenesis, and tissue growth. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into an adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. In cooperation with aPKC, required for the formation and maintenance of the rhabdomeric and stalk apical cortical membrane domains. Recruits aPKC to the apical stalk membrane where it phosphorylates and displaces rhabdomere specifying proteins such as PIP82, to restrict their localization and thus activity to the rhabdomeric apical domain. Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos. The CGX complex is also required for cell proliferation in developing wing disks. In the CGX complex, acts with galla-1 or galla-2 to recruit Xpd and thus form the functional complex. Together with apn, plays a key role in trachea development at larval stages.
  • 基因功能參考文獻：
    1. Results demonstrate that the apical membrane localization of Crumbs is promoted by Dlg5. PMID: 27211898
    2. Several Crb mutant proteins accumulated abnormally in the rhabdomere and affected rhodopsin trafficking, suggesting that abnormal rhodopsin physiology contributes to Crb/CRB1-associated retinal degeneration. PMID: 28515229
    3. The regulation of Crumbs by Neur is not strictly essential, it contributes to epithelium remodeling in the posterior midgut and thereby facilitates the trans-epithelial migration of the primordial germ cells in early embryos. PMID: 28400441
    4. The data provide a molecular basis to explain how the apical determinant Crb can regulate homeostasis of epithelial cells by stabilising Notch at the apical membrane, thereby finetuning Notch pathway activity. PMID: 27899511
    5. Data presented here point to a critical role of Crumbs in regulating actomyosin dynamics, cell junctions and morphogenesis. PMID: 26544546
    6. The Crumbs:Par-6 crystal structure reveals specific PDZ-peptide contacts that contribute to its higher affinity. PMID: 26894406
    7. regulation of Crumbs alternative splicing by the Obelus helicase modulates epithelial polarity during development PMID: 26644515
    8. RNKR motif in Crumbs mediates interaction with Sar1 and contributes to efficient ER export. PMID: 25753515
    9. phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin PMID: 25792740
    10. Crumbs localisation in the principal cells of the hindgut depends on Stardust. In contrast, localisation of Crumbs in the boundary cells does not require Stardust and is independent of its PDZ domain- and FERM-domain binding motifs. PMID: 24710316
    11. As well as repressing Yki by recruiting Ex to the apical membrane, Crb promotes phosphorylation-dependent ubiquitin-mediated degradation of Ex. PMID: 24778256
    12. The structure function analysis identified intracellular domain of Crb to be required for Abeta42-mediated-neurodegeneration. PMID: 24260128
    13. role in cell apical polarity and cell shape stabilisation PMID: 23525000
    14. The data demonstrate that the function of crb in photoreceptor development and homeostasis is conserved in compound eyes and ocelli and underscores the evolutionarily relationship between these visual sense organs of Drosophila. PMID: 22608020
    15. The only crucial function of Patj hinges on the ability of its first two domains to positively regulate the Crumbs complex, defining a new developmental level of regulation of its dynamics. PMID: 23136386
    16. an anisotropic plasma membrane distribution of Crumbs, mediated by its extracellular domain, determines the subcellular localization of a supracellular actomyosin cable at the placode border, with myosin II accumulating at edges where Crumbs is lowest PMID: 23153493
    17. Data suggest that Crumbs (Crb) may be part of a "surveillance mechanism" that is responsible for the cell death. PMID: 22683826
    18. Positive feedback and mutual antagonism combine to polarize Crumbs in the Drosophila follicle cell epithelium. PMID: 22658591
    19. Crb complex and Par proteins are critical during photoreceptor morphogenesis. PMID: 22025631
    20. controls epithelial integrity by inhibiting Rac1 and PI3K PMID: 21984807
    21. Crb protects against degeneration by interacting with and stabilizing MyoV, thereby ensuring correct rhodopsin 1 trafficking. PMID: 22105348
    22. In the absence of retromer, Crb was mis-targeted into lysosomes and degraded, causing a disruption of the apical-basal polarity. PMID: 21958744
    23. Regulated Crb accumulation controls apical constriction and invagination in tracheal cells. PMID: 21172808
    24. Crumbs overexpression leads to mislocalization of Expanded away from the apical cortex, which is predicted to deregulate the pathway. PMID: 20362447
    25. identify the transmembrane protein Crumbs (Crb), a determinant of epithelial apical-basal polarity in Drosophila embryos, as an upstream component of the Hippo pathway in imaginal disk growth control. PMID: 20498073
    26. show that Drosophila melanogaster Crumbs, a transmembrane protein controlling cell polarity and morphogenesis, is synthesized with an 83 residues-long signal sequence. PMID: 20189678
    27. crb function is not required for maintaining epithelial integrity during the morphogenesis of the head and eye. PMID: 20110329
    28. Interacts with Stardust to control polarity of epithelia but not neuroblasts. PMID: 11740559
    29. Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. PMID: 11744384
    30. control the position and integrity of the photoreceptor adherens junction and photosensitive organ, or rhabdomere PMID: 11850624
    31. apical transmembrane protein Crumbs is a central regulator of epithelial apical-basal polarity in Drosophila; central component of a molecular scaffold that controls zonula adherens assembly and defines the stalk as an apical membrane subdomain PMID: 11850625
    32. mutations in Drosophila crumbs result in progressive, light-induced retinal degeneration PMID: 12361571
    33. crb plays a role in salivary tube development in Drosophila PMID: 12526813
    34. crumbs has a role in regulating epithelial cell polarity in Drosophila along with DaPKC PMID: 15302858
    35. Analysis of yurt crb double mutants suggests that these genes function in one pathway and that yurt negatively regulates crb. PMID: 16950127
    36. study reports that Lin-7, a scaffolding protein with one Lin-2/Lin-7 domain & one PSD-95/Dlg/ZO-1 domain, is associated with the Crumbs complex in subapical region of embryonic & follicle epithelia & at the stalk membrane of adult photoreceptor cells PMID: 18177979
    37. Dynein-mediated messenger RNA transport coupled with a localized translation mechanism is involved in localizing Crb to the apical domain to mediate epithelial apicobasal polarity PMID: 18195099
    38. Study shows that the absence of zygotic function of Rho1 results in the selective loss of the apical proteins, Crumbs, Drosophila atypical PKC and Stardust during gland invagination and that this is due to reduced crb RNA levels and apical localization. PMID: 18585373

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  • 亞細胞定位：
    Apical cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    Crumbs protein family
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG6383

    STRING: 7227.FBpp0293268

    UniGene: Dm.2365



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