Recombinant Drosophila melanogaster Presenilin homolog (Psn), partial

中文名稱：

黑腹果蠅Psn重組蛋白
貨號(hào)：

CSB-YP522328DLU
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

黑腹果蠅Psn重組蛋白
貨號(hào)：

CSB-EP522328DLU
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

黑腹果蠅Psn重組蛋白
貨號(hào)：

CSB-EP522328DLU-B
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅Psn重組蛋白
貨號(hào)：

CSB-BP522328DLU
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

黑腹果蠅Psn重組蛋白
貨號(hào)：

CSB-MP522328DLU
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Psn
Uniprot No.：

O02194
別名：

Psn; PS; CG18803; Presenilin homolog; DmPS; EC 3.4.23.-; dPS
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes.
基因功能參考文獻(xiàn)：
1. Psn is required for neuronal survival during aging and normal lifespan. PMID: 28495961
2. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Diseaseprecursor protein (APP) vesicles PMID: 23710041
3. a conserved role for presenilin in mediating copper uptake PMID: 23667524
4. The interaction of Sanpodo with Presenilin, a component of the gamma-secretase complex, is required for Notch activation. PMID: 23609534
5. Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein. PMID: 22814602
6. Loss of presenilin causes significantly decreased Notch signaling and neuron apoptosis and increased cytoplasm calcium. PMID: 22120070
7. presenilin plays a role in regulating intracellular calcium stores PMID: 19730737
8. Drosophila PS (Psn) protein undergoes endoproteolytic cleavage and forms a stable high molecular weight (HMW) complex PMID: 12388554
9. specific diaspartyl groups within the presenilin catalytic core of gamma-secretase mediate the cleavage of different substrates PMID: 15220354
10. presenilin, nicastrin, APH-1, and PEN-2, are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes PMID: 16103123
11. Psn familial Alzheimer's disease mutant activities were tightly linked to their age-of-onset values, providing evidence that disease severity in humans primarily reflects differences in PS mutant lesions. PMID: 16713961
12. evidence of learning and synaptic defects in a Drosophila psn mutant and strongly suggest a presynaptic role for presenilin in normal neuronal function. PMID: 17562530
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亞細(xì)胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

Peptidase A22A family
組織特異性：

Maternally expressed in nurse and follicle cells. In early embryos, expressed in all or most cells and later increases in CNS and epidermal tissues. In larvae, expression is seen in all imaginal disks, brain and optic lobes. In pupae, expression is seen i
數(shù)據(jù)庫(kù)鏈接：

KEGG: dme:Dmel_CG18803

STRING: 7227.FBpp0077850

UniGene: Dm.3254