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  4. Recombinant Drosophila melanogaster Polyhomeotic-proximal chromatin protein (ph-p), partial

Recombinant Drosophila melanogaster Polyhomeotic-proximal chromatin protein (ph-p), partial

  • 中文名稱：
    黑腹果蠅ph-p重組蛋白
  • 貨號：
    CSB-YP331073DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅ph-p重組蛋白
  • 貨號：
    CSB-EP331073DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅ph-p重組蛋白
  • 貨號：
    CSB-EP331073DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅ph-p重組蛋白
  • 貨號：
    CSB-BP331073DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅ph-p重組蛋白
  • 貨號：
    CSB-MP331073DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ph-p
  • Uniprot No.：
  • 別名：
    ph-p; CG18412; Polyhomeotic-proximal chromatin protein
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Plays a role in regulating the expression of other pair-rule genes such as eve, ftz, and H.
  • 基因功能參考文獻：
    1. Organization of PcG proteins into small, abundant clusters on chromatin through Polyhomeotic protein sterile alpha motif polymerization activity may shape genome architecture through chromatin interactions. PMID: 26759081
    2. Polycomb protein Polyhomeotic mutants lacking the S/T stretch reproduce the phenotype of ogt mutants PMID: 25468754
    3. Ph sterile alpha motif polymerization is required for Ph-mediated gene repression. PMID: 22275371
    4. Data show that cells in an epithelium expressing different levels of polyhomeotic sort out indicating differential adhesive properties between the cell populations. PMID: 21085656
    5. We analyzed the cell cycle role of the proximal subunit of Polyhomeotic (PhP) in Drosophila PMID: 20045683
    6. Our results show a functional relationship between the PcG gene expression and the JAK/STAT pathway, both of which are found to be perturbed in tumorigenesis. PMID: 19923887
    7. Ph SAM domain forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes PMID: 11992127
    8. neofunctionalization has been achieved in the Drosophila ph genes through the action of strong positive selection and the inactivation of gene conversion in part of the gene. PMID: 18381818

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Salivary glands.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG18412

    STRING: 7227.FBpp0070416

    UniGene: Dm.5733



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