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  4. Recombinant Drosophila melanogaster Peptidoglycan-recognition protein LC (PGRP-LC), partial

Recombinant Drosophila melanogaster Peptidoglycan-recognition protein LC (PGRP-LC), partial

  • 中文名稱：
    黑腹果蠅PGRP-LC重組蛋白
  • 貨號：
    CSB-YP861956DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-LC重組蛋白
  • 貨號：
    CSB-EP861956DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-LC重組蛋白
  • 貨號：
    CSB-EP861956DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-LC重組蛋白
  • 貨號：
    CSB-BP861956DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-LC重組蛋白
  • 貨號：
    CSB-MP861956DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PGRP-LC
  • Uniprot No.：
  • 別名：
    PGRP-LC; ird7; PGRPLC; CG4432Peptidoglycan-recognition protein LC; Immune response deficient 7 protein
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns.; Mediates the response to LPS and Gram-negative bacteria.; Mediates the response to LPS, peptidoglycan and Gram-negative bacteria.
  • 基因功能參考文獻：
    1. cleaning behavior can be triggered through recognition of DAP-type PGN by its receptor PGRP-LC. PMID: 29121087
    2. this study identifies a novel version of the peptidoglycan receptor PGRP-LC and demonstrate that it tunes immune responses to live (threatening) or dead (harmless) bacteria PMID: 27548432
    3. PGRP-LC immune receptor regulates trans-synaptic signaling, a novel activity for innate immune signaling. PMID: 26687223
    4. The steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP-LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection. PMID: 23652443
    5. Data show that the Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway. PMID: 21372849
    6. required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-kappaB family transcription factor Relish PMID: 11872802
    7. Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. PMID: 11912488
    8. Drosophila receptor for E. coli: essential component for recognition and signalling of Gram-negative bacteria PMID: 11912489
    9. Using RNA interference in Drosophila mbn-2 cells, we found that PGRP-LCx is the only isoform required to mediate signals from Gram-positive bacteria and purified bacterial peptidoglycan. PMID: 12777387
    10. PGRP-LC functions synergistically with PGRP-LE in producing resistance to Escherichia coli and Bacillus megaterium infections. PMID: 15538387
    11. PGRP-LC acts as a signal-transducing innate immune receptor. PMID: 15657141
    12. crystal structure at 2.1 angstrom resolution of tracheal cytotoxin (TCT) in complex with the ectodomains of PGRP-LCa and PGRP-LCx shows that TCT is bound to and presented by the LCx ectodomain for recognition by the LCa ectodomain PMID: 16556841
    13. Interaction with the imd signaling protein is not required for PGRP-LC signaling. Instead, PGRP-LC signals through a receptor-interacting protein homotypic interaction motif-like motif. PMID: 16767093
    14. Toll and immune deficiency pathway of PGRP-LC activate an immune response in Drosophila melanogaster. PMID: 17438142
    15. Cleavage or down-regulation of PGRP-LC may provide an additional cue for the host to distinguish pathogenic microbes and subsequently activate multiple host defense systems in Drosophila, thereby combating bacterial infection and initiating tissue repair. PMID: 18308747
    16. By genetically interacting with PGRP-LC, PGRP-LF prevents constitutive activation of both the JNK and the immune deficiency pathways in the absence of infection. PMID: 18474356

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  • 亞細胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    N-acetylmuramoyl-L-alanine amidase 2 family
  • 組織特異性：
    Expressed in the fat body and hemocytes.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG4432

    STRING: 7227.FBpp0088492

    UniGene: Dm.1437



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