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  4. Recombinant Drosophila melanogaster Metabotropic glutamate receptor (mGluRA), partial

Recombinant Drosophila melanogaster Metabotropic glutamate receptor (mGluRA), partial

  • 中文名稱：
    黑腹果蠅mGluR重組蛋白
  • 貨號：
    CSB-YP309352DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅mGluR重組蛋白
  • 貨號：
    CSB-EP309352DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅mGluR重組蛋白
  • 貨號：
    CSB-EP309352DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅mGluR重組蛋白
  • 貨號：
    CSB-BP309352DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅mGluR重組蛋白
  • 貨號：
    CSB-MP309352DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    mGluR
  • Uniprot No.：
  • 別名：
    mGluR; Glu-RA; GluRA; mGluRA; CG11144Metabotropic glutamate receptor; DmGluRA
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.
  • 基因功能參考文獻：
    1. transgenic flies expressing a number of GPCRs in the photoreceptor cells PMID: 11964379
    2. sterol-rich lipid rafts act as positive allosteric regulators of DmGluRA. PMID: 12923296
    3. Two roles were found for DmGluRA in presynaptic mechanisms: (1) modulation of presynaptic excitability properties important for control of activity-dependent neurotransmitter release and (2) modulation of synaptic architecture. PMID: 15483129
    4. Metabotropic glutamate receptor A (mGluRA) and fragile X mental retardation (Fmr) protein genetically interact in behavioral movement regulation. PMID: 18280750
    5. we report DmGluRA expression in most neuropile areas in both larvae and adults, but not in the lobes of the mushroom bodies PMID: 18303583
    6. DmGluRA mutations increase neuronal excitability by preventing PI3 kinase (PI3K) activation and consequently hyperactivating the transcription factor Foxo PMID: 19043547

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 組織特異性：
    Expressed in the neurons of the larval CNS from the beginning of the first until the third instar. Expression in the third-instar larval CNS is restricted to a discrete number of somas and projections in the brain lobes and in the ventral ganglion. In the
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG11144

    STRING: 7227.FBpp0305080

    UniGene: Dm.1789



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