Recombinant Drosophila melanogaster Importin subunit alpha (Pen), partial

中文名稱：

黑腹果蠅Pen重組蛋白
貨號：

CSB-YP344775DLU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅Pen重組蛋白
貨號：

CSB-EP344775DLU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅Pen重組蛋白
貨號：

CSB-EP344775DLU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅Pen重組蛋白
貨號：

CSB-BP344775DLU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅Pen重組蛋白
貨號：

CSB-MP344775DLU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pen
Uniprot No.：

P52295
別名：

Pen; CG4799; Importin subunit alpha; Karyopherin subunit alpha; Pendulin
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs.; It is required for normal cell proliferation and may serve as an adapter molecule to form complexes with other proteins. May act as a tumor suppressor in hematopoietic cells. May play a role in the nuclear import of karyophilic proteins and some of these may be required for the normal transmission and function of proliferative signals in the cells.
基因功能參考文獻(xiàn)：
1. Importin-alpha2 is needed for some processes in the development of both the nervous system and the larval musculature PMID: 21151903
2. Wnt-activated growth of the postsynaptic membrane is mediated by the synapse-to-nucleus translocation and active nuclear import of Fz2-C via a selective Importin-beta11/alpha2 pathway. PMID: 20601947
3. Imp-alpha 2 protein plays a critical role in Kelch function by regulating its deposition on ring canals during their assembly. PMID: 12435357
4. each Imp-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes PMID: 12490175
亞細(xì)胞定位：

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus in a cell cycle-dependent manner.
蛋白家族：

Importin alpha family
組織特異性：

Predominantly expressed in the neuroblast stem cells.
數(shù)據(jù)庫鏈接：

KEGG: dme:Dmel_CG4799

STRING: 7227.FBpp0079527

UniGene: Dm.3560