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  4. Recombinant Drosophila melanogaster Homeobox protein prospero (pros), partial

Recombinant Drosophila melanogaster Homeobox protein prospero (pros), partial

  • 中文名稱：
    黑腹果蠅pros重組蛋白
  • 貨號：
    CSB-YP326906DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅pros重組蛋白
  • 貨號：
    CSB-EP326906DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅pros重組蛋白
  • 貨號：
    CSB-EP326906DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅pros重組蛋白
  • 貨號：
    CSB-BP326906DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅pros重組蛋白
  • 貨號：
    CSB-MP326906DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    pros
  • Uniprot No.：
  • 別名：
    CG17228; Homeobox protein prospero; Pro; PROS 1; PROS 2; proS; PROS_DROME; PROS1; PROS2; Prosp; Voila
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Homeodomain protein that controls neuronal identity. As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd. Required for proper neuronal differentiation, axonal outgrowth and pathfinding of most or all neurons and their precursors in central and peripheral nervous systems. Regulates asymmetric stem cell self-renewal together with brat.
  • 基因功能參考文獻：
    1. Loss of Prospero hinders the suppression of SCA8 associated neurodegeneration by Spoonbill. Prospero and Spoon might genetically interact and function together. PMID: 28722203
    2. Prospero is required for the differentiation of astrocytes, but not of ensheathing glia, despite their common lineage. PMID: 26893340
    3. Bj1 RanGEF promotes Prospero nuclear export and neuroblast self-renewal PMID: 25312250
    4. Transient nuclear Prospero induces neural progenitor quiescence. PMID: 25354199
    5. The results of this study suggested that Prospero restricts CO(2) neuron formation indirectly via miR-279 and directly by repressing the shared target molecules, Nerfin-1 and Esg. PMID: 22049409
    6. the homeo-prospero domain coordinately regulates Prospero nuclear localization and DNA binding specificity PMID: 12429095
    7. Subcellular localization of the transcription factor Prospero is dynamic. The carboxy terminus, including the homeodomain and Prospero domain, plays a roles in regulating these changes. PMID: 12529405
    8. The complete development of the nervous system requires a full complement of Pros, and that a gradual decrease in the levels of this protein can proportionally alter the development and the function of the nervous system. PMID: 12605454
    9. expression in combination with seven-up and elav identifies progenitor cell types during sense-organ differentiation in the Drosophila antenna PMID: 12606283
    10. Pros is a transcription factor which controls the distinction between color photoreceptor cell fates. PMID: 12791270
    11. Results identify an intron region critical for prospero twintron splicing as a first step towards elucidating the molecular mechanism of splicing regulation involving competition between the two kinds of spliceosomes. PMID: 14966268
    12. The neural precursor gene prospero is essential for nerfin-1 expression in the developing Drosophila central nervous system. PMID: 15617679
    13. DTRAF1 binds to Baz and acts downstream of Egr in the Mira/Pros telophase rescue pathway. PMID: 17139248
    14. Spatio-temporal expression of Prospero is finely tuned to allow the correct development and function of the nervous system in Drosophila melanogaster. PMID: 17223099
    15. Altered prospero expression affects the age of onset of male mating behavior. PMID: 17436071
    16. In the compound eye, prospero (pros) is transcribed specifically in R7 photoreceptors and cone cells. PMID: 18635611
    17. transcription factor transported to the nucleus during Drosophila embryonic nervous system development PMID: 11262236

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  • 亞細胞定位：
    Nucleus. Cytoplasm, cell cortex. Cytoplasm.
  • 蛋白家族：
    Prospero homeodomain family
  • 數(shù)據庫鏈接：

    KEGG: dme:Dmel_CG17228

    STRING: 7227.FBpp0293146

    UniGene: Dm.7116



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