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  4. Recombinant Drosophila melanogaster Homeobox protein abdominal-B (Abd-B)

Recombinant Drosophila melanogaster Homeobox protein abdominal-B (Abd-B)

  • 中文名稱：
    Recombinant Drosophila melanogaster Homeobox protein abdominal-B(Abd-B)
  • 貨號：
    CSB-YP362589DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Homeobox protein abdominal-B(Abd-B)
  • 貨號：
    CSB-EP362589DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Homeobox protein abdominal-B(Abd-B)
  • 貨號：
    CSB-EP362589DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Homeobox protein abdominal-B(Abd-B)
  • 貨號：
    CSB-BP362589DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Homeobox protein abdominal-B(Abd-B)
  • 貨號：
    CSB-MP362589DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Abd-B
  • Uniprot No.：
  • 別名：
    Abd-B; CG10291Homeobox protein abdominal-B; Infraabdominal 7; IAB-7; P3; PH189
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-493
  • 氨基酸序列
    MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH SAHPHLQQQQ QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP PPVPLVAVQQ QHLPAPQQQQ QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA SSNLQQQQQQ QNAAVAPGQT QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP GFETDTSAAV KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY PSENYSSSGA SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL ELEKEFLFNA YVSKQKRWEL ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL SLNMGHHAAK MHQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能參考文獻：
    1. analysis of blocking and bypass activities of the Fab-8 boundary in the Drosophila bithorax complex PMID: 27428541
    2. Abd-B is required in neurons during development for females to become highly receptive to male courtship. Abd-B neurons control pausing, a key aspect of female sexual receptivity, in response to male courtship. PMID: 24998527
    3. ABD-B binds more strongly to oligonucleotides containing two 5'-TTAT-3' canonical core motifs than the probe containing the 5'-TTAC-3' motif. PMID: 24219869
    4. Abd-B provides cues for integrin localization, critical for stem cell positioning. PMID: 24480643
    5. We also found that Abd-B expression in the secondary cells contributes to glycosylation of at least three accessory gland proteins: ovulin (Acp26Aa), CG1656, and CG1652 PMID: 23555301
    6. By functionally dissecting the Abd-B protein, new features of Abd-B dependent target gene regulation were detected. PMID: 22005458
    7. The promoter targeting sequences (PTS) from Abd-B locus overcome the enhancer blocking effect of insulators and facilitate long-range enhancer-promoter interactions in transgenic flies PMID: 20045684
    8. Studies indicate that interaction of Abdominal-B (ABD-B) with dorso ventral and intrasegmental positional information leads to the local activation of ABD-B primary targets in the dorsal region of the eighth abdominal segment (A8). PMID: 19247941
    9. The analysis of these mutations has allowed us to define a new infraabdominal-8 regulatory region, located 5' to the Abdominal-B transcription unit, and has helped to characterize better the complex regulation of the Abdominal-B gene. PMID: 12399311
    10. The promoter targeting sequence (PTS) from the Abdominal-B locus of the bithorax complex facilitates the activity of a distantly located enhancer in transgenic embryos and it restricts the enhancer to a single promoter. PMID: 12490558
    11. the Fab-7 boundary contains separable regions that function at different stages of development PMID: 15329342
    12. Abd-B acts at multiple levels to regulate gonad development and is a conserved factor in establishing gonad sexual dimorphism in diverse species. PMID: 15454263
    13. certain mutations in Abd-B can be rescued in trans by the other copy of the gene in the genetic phenomenon known as transvection PMID: 15572134
    14. Abdominal-B Hox protein directly activates expression of the yellow pigmentation gene in posterior segments PMID: 16814723
    15. Regulatory regons seems to control specifically the level of Abd-B expression in only one parasegment of the bithorax. PMID: 16818450
    16. Abdominal-B induces the expression of four intermediate signaling molecules and transcription factors; this expression results in the mosaic activation of several realizator genes during the organogenesis of the external respiratory organ of the larva. PMID: 17113384
    17. Enhancer interference limits the interaction of the Abdominal-B promoter to the enhancer(s) from only one regulatory domain in a specific abdominal segment. PMID: 17307884
    18. the enhancer blocking capability of the Fab-8 insulator in stably transfected Drosophila S2 cells and show this activity depends on the Fab-8 CTCF binding sites PMID: 17825318
    19. Fab-7 and Fab-8 boundaries effectively interact with the upstream region of the Abd-B promoter PMID: 18426914
    20. development of the dorsal histoblast nests that will give rise to the adult epithelium is impaired in the posterior segments which identity is specified by Abdominal-B PMID: 18667003
    21. Using gene conversion, we exchanged the Fab-7 and Fab-8 boundaries within the BX-C. PMID: 18987027

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 組織特異性：
    Isoform M and isoform R are expressed in ectodermal and mesodermal tissues and central nervous system of fourth to ninth embryonic abdominal segments. Later in embryogenesis, expression is seen in visceral mesoderm surrounding hindgut and in two Malpighia
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG11648

    STRING: 7227.FBpp0082826

    UniGene: Dm.1763



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