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  4. Recombinant Drosophila melanogaster E3 ubiquitin-protein ligase highwire (hiw), partial

Recombinant Drosophila melanogaster E3 ubiquitin-protein ligase highwire (hiw), partial

  • 中文名稱：
    黑腹果蠅hiw重組蛋白
  • 貨號：
    CSB-YP885654DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅hiw重組蛋白
  • 貨號：
    CSB-EP885654DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅hiw重組蛋白
  • 貨號：
    CSB-EP885654DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅hiw重組蛋白
  • 貨號：
    CSB-BP885654DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅hiw重組蛋白
  • 貨號：
    CSB-MP885654DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    hiw
  • Uniprot No.：
  • 別名：
    hiw; CG32592; E3 ubiquitin-protein ligase highwire; EC 2.3.2.-; Protein pam/highwire/rpm-1
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues. Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ) together with Rae1 and Fsn.
  • 基因功能參考文獻：
    1. Results indicate that the ability of faf, hiw or Rdl to modulate sleep and protect against cognitive impairments during waking is circuit dependent. Decreasing hiw and Rdl within the Mushroom Bodies protects against the negative effects of sleep deprivation as indicated by the absence of a subsequent homeostatic response, or deficits in short-term memory. PMID: 29109678
    2. Highwire promotes axon termination, pruning and synaptogenesis. PMID: 28100586
    3. The dual leucine zipper kinase (DLK) signaling pathway in Drosophila, which consists of Highwire and Wallenda and controls axonal growth, regeneration, and degeneration, is also involved in dendritic growth in vivo. PMID: 23750116
    4. An increased level of Nmnat protein in hiw mutants is both required and sufficient to inhibit axonal degeneration. PMID: 23226106
    5. Genetic interaction studies suggest that Highwire and Plexin A signals may interact to regulate normal morphogenesis of alpha/beta axons. PMID: 22131429
    6. The regulation of Wnd protein turnover by Hiw can function as a damage surveillance mechanism for responding to axonal injury. PMID: 20921142
    7. BMP signaling mutants suppress the excessive synaptic growth in Highwire mutants. Activation of BMP signaling in Highwire mutants causes further synaptic expansion. PMID: 15046722
    8. Highwire may independently regulate the molecular pathways controlling synaptic growth and function. PMID: 16237161
    9. These results suggest that Highwire controls structural plasticity of the synapse by regulating gene expression through a MAP kinase signaling pathway. PMID: 16815332

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  • 亞細胞定位：
    Cell junction, synapse. Cell projection, axon.
  • 蛋白家族：
    Highwire family
  • 組織特異性：
    Express throughout the nervous system. Stage 13 embryos show expression in the central nervous system (CNS) at the longitudinal axon tracts around which the synaptic neuropil forms. Expression outside the CNS starts at stage 16 in presynaptic terminals at
  • 數據庫鏈接：


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