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  4. Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein B (CrebB-17A)

Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein B (CrebB-17A)

  • 中文名稱：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein B(CrebB-17A)
  • 貨號：
    CSB-YP894749DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein B(CrebB-17A)
  • 貨號：
    CSB-EP894749DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein B(CrebB-17A)
  • 貨號：
    CSB-EP894749DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein B(CrebB-17A)
  • 貨號：
    CSB-BP894749DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein B(CrebB-17A)
  • 貨號：
    CSB-MP894749DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CrebB
  • Uniprot No.：
  • 別名：
    CrebB; CrebB-17A; CG6103Cyclic AMP response element-binding protein B; cAMP response element-binding protein B; dCREB-B
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-359
  • 氨基酸序列
    MDNSIVEENG NSSAASGSND VVDVVAQQAA AAVGGGGGGG GGGGGGNPQQ QQQNPQSTTA GGPTGATNNA QGGGVSSVLT TTANCNIQYP IQTLAQHGLQ VSIWGPGAWC QLSSVRCYGS QPEVATKDVQ SVIQANPSGV IQTAAGTQQQ QQALAAATAM QKVVYVAKPP NSTVIHTTPG NAVQVRNKIP PTFPCKIKPE PNTQHPEDSD ESLSDDDSQH HRSELTRRPS YNKIFTEISG PDMSGASLPM SDGVLNSQLA GTGAGGNAAN SSLMQLDPTY YLSNRMSYNT NNSGIAEDQT RKREIRLQKN REAARECRRK KKEYIKCLEN RVAVLENQNK ALIEELKSLK ELYCQTKND
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Isoform E is a PKA-dependent transcriptional activator. Isoform J is a direct antagonist of activation by isoform E in cell culture. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Has a role in long-term memory.
  • 基因功能參考文獻：
    1. Early-onset sleep defects in mutated HTT Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling. PMID: 26604145
    2. changes suggest that dCREB2 functions in both the ellipsoid body and the mushroom body for long term memory formation, and that this activity contributes to the process of systems consolidation. PMID: 25460038
    3. Our data suggest the model that Notch and PKC activities generate a cyclical accumulation of cytoplasmic hyper-PO4 CREB that is a precursor for generating the nuclear CREB isoforms. PMID: 23904617
    4. Overexpression of a dCREB2 activator can enhance memory formation. PMID: 23616553
    5. in light-light conditions, dCREB2 and NF-kappaB reporter flies exhibit suppression of rhythmic activity. Neuronal cycling of dCREB2 and NF-kappaB activity are modulated in period mutant flies, indicating these oscillations are controlled through the central clock PMID: 23077489
    6. This study demonstrates that CREB activity in either neuronal or peripheral tissues regulates energy balance in Drosophila. PMID: 20041126
    7. Isoform, dCREB2-b, is a repressor of dCREB2-a. Here, we demonstrate that overexpression of dCREB2-b in virgin females enhances their sexual receptivity. PMID: 12467339
    8. cAMP-response element-binding protein DNA binding in Drosophila is regulated by phosphorylation of conserved casein kinase sites PMID: 14676200

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 組織特異性：
    Most cells of the adult brain; cell bodies, but not neuropil.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG6103

    STRING: 7227.FBpp0074326

    UniGene: Dm.26256



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