在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Drosophila melanogaster Circadian locomoter output cycles protein kaput (Clk), partial

Recombinant Drosophila melanogaster Circadian locomoter output cycles protein kaput (Clk), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Circadian locomoter output cycles protein kaput(Clk) ,partial
  • 貨號：
    CSB-YP005574DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Circadian locomoter output cycles protein kaput(Clk) ,partial
  • 貨號：
    CSB-EP005574DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Circadian locomoter output cycles protein kaput(Clk) ,partial
  • 貨號：
    CSB-EP005574DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Circadian locomoter output cycles protein kaput(Clk) ,partial
  • 貨號：
    CSB-BP005574DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Circadian locomoter output cycles protein kaput(Clk) ,partial
  • 貨號：
    CSB-MP005574DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Clk
  • Uniprot No.：
  • 別名：
    Clk; CLOCK; jrk; PAS1; CG7391Circadian locomoter output cycles protein kaput; dCLOCK; dPAS1
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to PubMed:9742131, reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas PubMed:9616122 describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced, Period and Timeless block Clock's ability to transactivate their promoters.
  • 基因功能參考文獻：
    1. experiments define the genetic architecture required to initiate circadian clock function in Drosophila, reveal mechanisms governing circadian activator stability that are conserved in perhaps all eukaryotes, and suggest that Clk, cyc, and cry expression is sufficient to drive clock expression in naive cells PMID: 28973907
    2. propose that the dCLK/CYC-controlled TTFL operates differently in subsets of pacemaker neurons, which may contribute to their specific functions PMID: 27489346
    3. ClkAR mutants showed significantly faster age-related locomotor deficits. Accelerated locomotor decline of the ClkAR mutant required expression of the PDF receptor and correlated to an apparent loss of dopaminergic neurons in the brain PMID: 28072817
    4. these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription. PMID: 25952406
    5. Our findings suggest a novel role for clock protein phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression. PMID: 25121504
    6. These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop. PMID: 24872414
    7. Computational dissection of CLK/CYC context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites PMID: 24332542
    8. usp8 loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8-DN) enhances CLK/CYC transcriptional activity and alters fly locomotor activity rhythms PMID: 23154984
    9. CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation PMID: 22085964
    10. dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation PMID: 20980603
    11. findings show that Clk and cyc act during starvation to modulate the conflict of whether flies sleep or search for food PMID: 20541409
    12. Here we examined the consequences of loss of clock function on reproductive fitness in Drosophila melanogaster with mutated period (per(0)), timeless (tim(0)), cycle (cyc(0)), and Clock (Clk(Jrk)) genes PMID: 11854509
    13. dCLK levels are critical in mediating the direct photostimulation of locomotor activity in Drosophila. PMID: 11931742
    14. constitutive levels of nuclear CLK regulate rhythmic transcription in circadian oscillator cells and CLK contributes to other behavioral processes by regulating gene expression in non-oscillator cells PMID: 16603674
    15. findings suggest that Clockwork Orange (CWO) acts preferentially in the late night to help terminate CLK-CYC-mediated transcription of direct target genes including cwo itself PMID: 17578907
    16. Cwo is rhythmically expressed and directly regulated by CLK-CYC through canonical E-box sequences. PMID: 17578908
    17. Results indicate that, in vivo, clockwork orange (CWO) modulates clock gene expression through both repressor and activator transcriptional functions. PMID: 18375860
    18. These results define the temporal and spatial coordinates of factors that initiate Clk expression, imply that circadian photoreceptors are not activated until the end of embryogenesis. PMID: 19094242
    19. DBT plays a novel noncatalytic role in recruiting additional kinases that phosphorylate CLK, thereby repressing transcription PMID: 19139270
    20. the post-translational processing of the circadian CLOCK protein by Cytoplasmic interaction with CYCLE protein PMID: 19376119
    21. Sequential phosphorylation and subcellular distribution regulate the activity of the CLK protein. PMID: 19564332
    22. Results reveal clear heterogeneity in Clock gene expression in the brain and provide a necessary focus to isolate novel transcription factors that bind at the Clk locus to regulate expression in different oscillator neuron subgroups. PMID: 19755581

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Widely expressed. Found in head, body, and appendage fractions.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG7391

    STRING: 7227.FBpp0099478

    UniGene: Dm.7596



主站蜘蛛池模板： 永久免费的av片在线电影网| 久久久久久一区国产精品| 尤物蜜芽国产成人精品区| 欧美成人无码a区视频在线观看| 亚洲国产桃花岛一区二区| 日本精品高清一区二区| 久久精品国产色蜜蜜麻豆| 亚洲色成人一区二区三区小说| 亚洲综合av色婷婷五月蜜臀| 国产va免费精品观看| 亚洲综合久久一本伊一区| 亚洲欧美在线观看| 躁躁躁日日躁| 永久免费的无码中文字幕| 国产午夜a理论毛片| 又大又粗又长的高潮视频| 午夜亚洲福利在线老司机| 无码精品人妻一区二区三区免费看| 国内大量揄拍人妻精品視頻| 99久久国产露脸精品| 亚洲人成电影在线天堂色| 少妇久久久久久被弄高潮| 一区二区三区在线 | 网站| 中文字幕av中文字无码亚| 久久婷婷五月综合中文字幕| 少妇大叫太大太爽受不了| 人妻熟女一区| 人人妻人人妻人人片av| 人妻少妇精品视频无码专区| 亚洲大尺度专区无码浪潮av| 在线精品自偷自拍无码| 女子spa高潮呻吟抽搐| 精品国产一区av天美传媒| 久久综合97丁香色香蕉| 亚洲精品无码久久久久秋霞| 国产无遮挡又黄又爽在线观看| 人妻中文无码久热丝袜| 欧洲美熟女乱又伦免费视频| 九九视频麻婆豆腐在线观看| 亚洲精品久久久久午夜福禁果tⅴ| 无码专区aaaaaa免费视频|