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  4. Recombinant Drosophila melanogaster COP9 signalosome complex subunit 5 (CSN5)

Recombinant Drosophila melanogaster COP9 signalosome complex subunit 5 (CSN5)

  • 中文名稱：
    Recombinant Drosophila melanogaster COP9 signalosome complex subunit 5(CSN5)
  • 貨號：
    CSB-YP895497DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster COP9 signalosome complex subunit 5(CSN5)
  • 貨號：
    CSB-EP895497DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster COP9 signalosome complex subunit 5(CSN5)
  • 貨號：
    CSB-EP895497DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster COP9 signalosome complex subunit 5(CSN5)
  • 貨號：
    CSB-BP895497DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster COP9 signalosome complex subunit 5(CSN5)
  • 貨號：
    CSB-MP895497DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CSN5
  • Uniprot No.：
  • 別名：
    CSN5; quo; CG14884COP9 signalosome complex subunit 5; Dch5; Signalosome subunit 5; EC 3.4.-.-; JAB1 homolog
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-327
  • 氨基酸序列
    MDSDAAQKTW ELENNIQTLP SCDEIFRYDA EQQRQIIDAK PWEKDPHFFK DIKISALALL KMVMHARSGG TLEVMGLMLG KVEDNTMIVM DAFALPVEGT ETRVNAQAQA YEYMTAYMEA AKEVGRMEHA VGWYHSHPGY GCWLSGIDVS TQMLNQTYQE PFVAIVVDPV RTVSAGKVCL GAFRTYPKGY KPPNEEPSEY QTIPLNKIED FGVHCKQYYP LEISYFKSAL DRRLLDSLWN KYWVNTLGSS GLLTNTEYTT GQIMDLSEKL EQSENFLGRG TDVNEKRSED KLSKATRDCS RSTIELIHGL MAQIVKDKLF NKVGLGK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis. Also involved in regulation of axis formation by checkpoint-dependent, translational control of Gurken.
  • 基因功能參考文獻：
    1. during oogenesis CSN5/JAB1, one subunit of the CSN, is required for meiotic progression and for establishment of both the AP and DV axes of the Drosophila oocyte PMID: 12397113
    2. results presented here indicate that CSN5 is a negative regulator of Dorsal subcellular localization, and of hemocyte proliferation and differentiation PMID: 17295838
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase M67A family, CSN5 subfamily
  • 組織特異性：
    Expressed in the optic lobe neuropil.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG14884

    STRING: 7227.FBpp0082743

    UniGene: Dm.1223



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