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  4. Recombinant Drosophila melanogaster Beta-amyloid-like protein (Appl), partial

Recombinant Drosophila melanogaster Beta-amyloid-like protein (Appl), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Beta-amyloid-like protein(Appl) ,partial
  • 貨號：
    CSB-YP321270DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Beta-amyloid-like protein(Appl) ,partial
  • 貨號：
    CSB-EP321270DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Beta-amyloid-like protein(Appl) ,partial
  • 貨號：
    CSB-EP321270DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Beta-amyloid-like protein(Appl) ,partial
  • 貨號：
    CSB-BP321270DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Beta-amyloid-like protein(Appl) ,partial
  • 貨號：
    CSB-MP321270DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Appl
  • Uniprot No.：
  • 別名：
    Appl; CG7727Amyloid-beta-like protein
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    During development, plays a role in the regulation of the neddylation pathway. Appl and APP-BP1 interact antagonistically during development.
  • 基因功能參考文獻：
    1. Results show that Drosophila APPL-RNAi largely mimics transgenic amyloid beta in various phenotypes which include eye degeneration, reduced longevity and motor neuron deficit functions. This is the first report showing comparable phenotypes between APPL and amyloid beta in Alzheimer's disease model of Drosophila. PMID: 28336338
    2. Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate recycling. PMID: 28314820
    3. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide. PMID: 26274614
    4. The results of this study showed that increased production of the endogenous Drosophila Amyloid Intracellular Domain (dAICD) caused disruption of circadian rest-activity rhythms during aging. PMID: 25766673
    5. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes. PMID: 25609621
    6. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease PMID: 23710041
    7. APPL is the first example of a modulator of the Wnt-PCP pathway specifically required for axon outgrowth. PMID: 23690751
    8. Data show that Appl is directly regulated by the Ras/MAPK pathway through a mechanism mediated by PntP2. PMID: 23178937
    9. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation. PMID: 21912928
    10. Disruption of amyloid protein precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo. PMID: 22266106
    11. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. PMID: 22086926
    12. accumulation of Ass42 plaques induces JNK signaling in neurons and induction of JNK contributes to Ass42 mediated cell death PMID: 21949710
    13. Findings show that age-related changes in amyloid characteristics may be a trigger for late-onset polyglutamine diseases. PMID: 21466635
    14. in adult flies, APPL is not required for learning but is specifically involved in long-term memory, a long lasting memory whose formation requires de novo protein synthesis and is thought to require synaptic structural plasticity. PMID: 21248128
    15. Abeta42 levels were reduced upon GSK-3 inhibition, pointing to a direct role of GSK-3 in the regulation of Abeta42 peptide level, in the absence of APP processing. PMID: 20824130
    16. Data suggest that toxic effects of amyloid beta-peptide aggregation in vivo can therefore be eliminated by sequestration of hydrophobic regions in monomeric peptides, even when these are extremely aggregation prone. PMID: 20305716
    17. APP-Like (APPL) can induce postdevelopmental axonal arborization, which depends critically on a conserved motif in the C-terminus and requires interaction with the Abelson (Abl) tyrosine kinase. PMID: 16052209
    18. Study shows that APP-BP1 specifically binds the intracellular domain of APP-like protein (APPL), APP-BP1 mutation partially suppresses the abnormal macrochaete phenotype of Appl(d), while overexpression of dAPP-BP1 causes abnormal macrochaetes. PMID: 16628230
    19. These data offer insight into the toxicity of Abeta and open new areas for further study into Alzheimer's disease pathogenesis. PMID: 18245849
    20. findings show that Abeta fragments aggregate into intracellular fibrils, amyloid deposits, and cause age-dependent behavioral deficits and neurodegeneration PMID: 19049874
    21. yata mutants showed impaired subcellular localization of APPL. PMID: 19209226
    22. Results demonstrate that 53 of the modifiers genetically interacted with APP, and characterization of these genes may provide valuable insights into Presenilin function in development and disease. PMID: 19241393

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    APP family
  • 組織特異性：
    Expressed in postmitotic neurons in the central and peripheral nervous systems. Within the nervous system, transcripts are not observed in neuroblasts, newly generated neurons and at least one class of presumed glial cells.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG7727

    STRING: 7227.FBpp0298292

    UniGene: Dm.4862



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