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  4. Recombinant Dog Sodium/calcium exchanger 1 (SLC8A1), partial

Recombinant Dog Sodium/calcium exchanger 1 (SLC8A1), partial

  • 中文名稱：
    熟悉的犬SLC8A1重組蛋白
  • 貨號：
    CSB-YP021723DO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬SLC8A1重組蛋白
  • 貨號：
    CSB-EP021723DO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬SLC8A1重組蛋白
  • 貨號：
    CSB-EP021723DO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬SLC8A1重組蛋白
  • 貨號：
    CSB-BP021723DO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬SLC8A1重組蛋白
  • 貨號：
    CSB-MP021723DO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    SLC8A1; NCX1; Sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1; Solute carrier family 8 member 1
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
  • 基因功能參考文獻：
    1. knockdown of NCX1 in Madin-Darby canine kidney cells alters epithelial morphology and characteristics by destabilization of E-cadherin and induction of beta-catenin signaling. PMID: 28550085
    2. NCX1 palmitoylation is governed by a distal secondary structure element rather than by local primary sequence. PMID: 28432123
    3. Palmitoylation of NCX1 occurs in the Golgi and anchors the NCX1 large regulatory intracellular loop to membranes. PMID: 26174834
    4. These data confirm the role of NCX1 activity in regulating renal epithelial cell migration. PMID: 25770213
    5. f-loop residues 562-679 may contain the regulatory site for endogenous exchanger inhibitor peptide XIP, but this site is distinct from the Ca2+-regulatory domains of the NCX. PMID: 15550690
    6. NCX1 is a novel regulatory target for calcineurin; depressed NCX activity might contribute to the etiology of in vivo cardiac hypertrophy and dysfunction occurring under conditions in which both calcineurin and protein kinase C are chronically activated PMID: 15557343
    7. Endothelin-1 enhances the activity of Na+/Ca2+ exchanger type 1 in renal epithelial cells. PMID: 15838289
    8. Results suggest that Ca2+ overload via NCX1 plays a critical role in hypoxia/reoxygenation-induced renal tubular injury, and that endothelin-1 aggravates the cell damage through the activation of NCX1. PMID: 15838349
    9. crystal structure of CBD1 at 2.5A resolution, which reveals a novel Ca2+ binding site consisting of four Ca2+ ions arranged in a tight planar cluster, indicative of a highly sensitive Ca2+ sensor PMID: 16774926
    10. analysis of transmembrane segments 1, 2, and 6 in canine NCX1 PMID: 16785232
    11. Insertion of fluorescent-tagged Na+-Ca+ exchanger proteins within the large intracellular loop of canine NCX1 is well tolerated and leads to active transporters. PMID: 17158867
    12. Ca(2+) elicits a local transition to a well-ordered coordination geometry in the CBD1-binding site of NCX1. PMID: 18280495
    13. These results indicate that NCX-1 can be a biomarker for chronic valvular disease in dogs and is a potential biomarker for severity of heart disease. PMID: 19000248
    14. Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein. PMID: 19141619
    15. Phospholemman regulates cardiac Na+/Ca2+ exchanger by interacting with the exchanger's proximal linker domain. PMID: 19158404
    16. Structural and mutational analyses indicate that only two of the four Ca(2+) ions that bind to CBD1 of NCX1.1 are important for regulating exchanger activity. PMID: 19332552
    17. Data suggest that the electrostatic switch in CBD1 and the associated conformational change are necessary for Na+/Ca2+ exchanger activation. PMID: 19667209
    18. role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1 PMID: 20587421
    19. The expression of NCX-1 in dogs with chronic mitral valve insufficiency or azotemia showed that the latter does not affect NCX-1 expression. PMID: 21054542
    20. Data show that the Ca(2+)-dependent movements detected between paired NCXs were abolished by mutating the Ca(2+) coordination sites in CBD1. PMID: 21209335
    21. the second Ca(2+)-binding domain of NCX1 binds Mg2+ with high affinity PMID: 21928827
    22. mu-Calpain-mediated deregulation of cardiac, brain, and kidney NCX1 splice variants. PMID: 22209698
    23. The Ca(2+)-driven interdomain switch described here represents a general mechanism for initial conduction of regulatory signals in NCX variants. PMID: 22768191
    24. Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX). PMID: 23798674

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC8 subfamily
  • 組織特異性：
    Cardiac sarcolemma (at protein level).
  • 數據庫鏈接：


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