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  4. Recombinant Dog Endoplasmin (HSP90B1), partial

Recombinant Dog Endoplasmin (HSP90B1), partial

  • 中文名稱：
    熟悉的犬HSP90B1重組蛋白
  • 貨號：
    CSB-YP010814DO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬HSP90B1重組蛋白
  • 貨號：
    CSB-EP010814DO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬HSP90B1重組蛋白
  • 貨號：
    CSB-EP010814DO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬HSP90B1重組蛋白
  • 貨號：
    CSB-BP010814DO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬HSP90B1重組蛋白
  • 貨號：
    CSB-MP010814DO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    HSP90B1; GRP94; TRA1Endoplasmin; 94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10.
  • 基因功能參考文獻：
    1. Folding and domain interactions of three orthologs of Hsp90 have been reported. PMID: 29276035
    2. These findings suggest that Grp94 might act as a potential biomarker for prognosis of canine mammary tumors and monitoring its therapy. PMID: 28801701
    3. The results provide structural insight into the ATP-dependent client maturation process of GRP94. PMID: 28930677
    4. Increased HSP90 expression in canine PCs suggests the involvement of this molecule in carcinogenesis and tumour progression, supporting HSP90 as a potential target for therapeutic intervention. PMID: 24679854
    5. is a constitutively expressed molecular chaperone and plays an important role in the folding of client proteins with key regulatory roles in growth, survival, differentiation and metastasis. PMID: 24418710
    6. structural maturation of the client protein substrate, rather than ATP binding or hydrolysis, serves as the primary signal for dissociation of GRP94-client protein complexes PMID: 15236592
    7. Data report the 2.4 A crystal structure of GRP94 in complex with AMPPNP and ADP, and provide a structural explanation for GRP94's observed rate of ATP hydrolysis. PMID: 17936703
    8. expression of TLR2, but not TLR4, on synovial fluid macrophages strongly correlated with the level of gp96 in the synovial fluid PMID: 19342676
    9. The ATPase activity of GRP94 is essential for chaperone activity in vivo and the essential protein-binding domain of GRP94 is distinct from the N-terminal domain. PMID: 19553200

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  • 亞細胞定位：
    Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen. Melanosome.
  • 蛋白家族：
    Heat shock protein 90 family
  • 組織特異性：
    Detected in heart muscle (at protein level).
  • 數據庫鏈接：


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