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  4. Recombinant Dog Dystrophin (DMD), partial

Recombinant Dog Dystrophin (DMD), partial

  • 中文名稱：
    熟悉的犬DMD重組蛋白
  • 貨號：
    CSB-YP006963DO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬DMD重組蛋白
  • 貨號：
    CSB-EP006963DO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬DMD重組蛋白
  • 貨號：
    CSB-EP006963DO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬DMD重組蛋白
  • 貨號：
    CSB-BP006963DO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬DMD重組蛋白
  • 貨號：
    CSB-MP006963DO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    DMDDystrophin
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
  • 基因功能參考文獻：
    1. The deletion was confirmed with conventional PCR and Sanger sequencing. This mutation is in a secondary DMD gene hotspot area distinct from the one identified earlier at the 5' donor splice site of intron 50 in the CKCS breed. PMID: 28028563
    2. Partial myostatin loss may exaggerate selective muscle hypertrophy or atrophy/hypoplasia in dystrophin-deficient dogs and worsen contractures. PMID: 27047655
    3. a chromosome inversion disrupting the DMD and RPGR genes is the causative mutation for X-linked muscular dystrophy in the Japanese Spitz breed PMID: 25644216
    4. Data indicate that dystrophin affects caveolar integrity and airway smooth muscle contraction. PMID: 25054970
    5. These data are consistent with the notion that altered N-glycolylneuraminic acid and cytotoxic T cell carbohydrate expression may modify severity of muscular dystrophy resulting from dystrophin deficiency in dogs and humans. PMID: 24505439
    6. These data underscore the muscle-specific responses to dystrophin deficiency and the potential deleterious effects of differential muscle involvement. PMID: 24160322
    7. Data indicate extensive expression of skipped RNA and dystrophin protein in the treated myocardium. PMID: 22551778
    8. eccentric contractions induce greater-than-normal isometric torque drop in dystrophin-deficient dog muscles PMID: 20544944
    9. Stem cell transplantation does not improvse dystrophin expression in Duchenne muscular dystrophy. PMID: 15328150
    10. Dystrophin depletion closely coincided with generally depressed transcription and translation in acute ischemic myocardial injury and reperfusion. PMID: 15850566
    11. Selective vacuolar degeneration of Purkinje fibers was found in the early stages of dystrophin deficiency PMID: 18458171

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  • 亞細胞定位：
    Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane.
  • 數據庫鏈接：


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