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  4. Recombinant Dog Ceroid-lipofuscinosis neuronal protein 5 (CLN5)

Recombinant Dog Ceroid-lipofuscinosis neuronal protein 5 (CLN5)

  • 中文名稱：
    Recombinant Dog Ceroid-lipofuscinosis neuronal protein 5(CLN5)
  • 貨號：
    CSB-YP702501DO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Dog Ceroid-lipofuscinosis neuronal protein 5(CLN5)
  • 貨號：
    CSB-EP702501DO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Dog Ceroid-lipofuscinosis neuronal protein 5(CLN5)
  • 貨號：
    CSB-EP702501DO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Dog Ceroid-lipofuscinosis neuronal protein 5(CLN5)
  • 貨號：
    CSB-BP702501DO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Dog Ceroid-lipofuscinosis neuronal protein 5(CLN5)
  • 貨號：
    CSB-MP702501DO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CLN5
  • Uniprot No.：
  • 別名：
    CLN5Ceroid-lipofuscinosis neuronal protein 5; Protein CLN5) [Cleaved into: Ceroid-lipofuscinosis neuronal protein 5; secreted form]
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    36-350
  • 氨基酸序列
    AAGGP SRRQWPVPYK RFSFRPEPDP YCQAKYTFCP TGSPIPVMKG DDVIEVFRLQ TPVWEFKYGN LLGHLKIMHD AIGFKSTLTG KNYTMEWYEL FQLGNCTFPH LRPEMNAPFW CNQGAACFFE GIDDIHWKEN GTLVLVATIS GNTFNQMAKW VKRDNETGIY YETWTVQASP TKGAETWFES YDCSKFVLRT YKKLAELGAE FKKIETNYTR IFLYSGEPTY LGNETSIFGP TGNKTLALAI KRFYYPFKPH LSTKEFLLSI LQIFDAVIIH REFYLFYNFE YWFLPMKFPF IKITYEEIPL PKRNETLSGL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.
  • 基因功能參考文獻：
    1. Genome sequence from one affected dog, contained a plausibly causal homozygous mutation producing a frameshift and premature termination codon and encode a protein variant, which would lack 39 C-terminal amino acids in CLN5. PMID: 25934231
    2. Sequencing of CLN5 revealed a nonsense mutation (Q206X) within exon 4 that correlated with neuronal ceroid lipofuscinosis in Border collies PMID: 16033706
  • 相關疾病：
    Defects in CLN5 are the cause of neuronal ceroid lipofuscinosis (NCL). NCL is characterized by brain atrophy and the accumulation of lysosome derived fluorescent storage bodies in neurons and most other cells. NCL is found in Border collie dogs.
  • 亞細胞定位：
    [Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome.; [Ceroid-lipofuscinosis neuronal protein 5]: Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    CLN5 family
  • 數據庫鏈接：


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