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  4. Recombinant Danio rerio T-box transcription factor TBX5-A (tbx5a)

Recombinant Danio rerio T-box transcription factor TBX5-A (tbx5a)

  • 中文名稱：
    斑馬魚tbx5a重組蛋白
  • 貨號：
    CSB-YP881254DIL
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    斑馬魚tbx5a重組蛋白
  • 貨號：
    CSB-EP881254DIL
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    斑馬魚tbx5a重組蛋白
  • 貨號：
    CSB-EP881254DIL-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    斑馬魚tbx5a重組蛋白
  • 貨號：
    CSB-BP881254DIL
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    斑馬魚tbx5a重組蛋白
  • 貨號：
    CSB-MP881254DIL
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    tbx5a
  • Uniprot No.：
  • 別名：
    tbx5a; heartstrings; hst; tbx5; tbx5.1; si:ch211-245e21.2; T-box transcription factor TBX5-A; zftbx5a; T-box protein 5; zTbx5
  • 種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-492
  • 氨基酸序列
    MADSEDTFRL QNSPSDSEPK DLQNEGKSDK QNAAVSKSPS SQTTYIQQGM EGIKVYLHER ELWTKFHEVG TEMIITKAGR RMFPSFKVKV TGLNPKTKYI LLMDVVPADD HRYKFADNKW SVTGKAEPAM PGRLYVHPDS PATGAHWMRQ LVSFQKLKLT NNHLDPFGHI ILNSMHKYQP RIHIVKADEN NGFGSKNTAF CTHVFPETAF IAVTSYQNHK ITQLKIENNP FAKGFRGSDD MELHRMSRMQ STKEYPVVPR STVRQRVGSS QSPFSGDVQG LSASGAISSQ YSCENGVSST SQDLLPQSSS YHEHTQDYHC IKRKVEDECP AGEHPYKKPY VESSSSEDDH YYRPLSYSQS LGLSGGAPYR PESSQRQACM YASAPQPPEP VPSLEDISWP GVPPYSVPQM ERLPYQHHFS AHFASRQMPE AHGMYASSVS HQCSPSGGIQ SPSAGLQGNE YLYAHGLQRT LSPHQYHTVH SVSIMHDWNE AS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters.
  • 基因功能參考文獻：
    1. loss of tbx5a function significantly impairs the ability of zebrafish hearts to regenerate after ventricular resection, indicating that Tbx5a plays an essential role in the transcriptional program of heart regeneration. PMID: 29933372
    2. Tbx5a-expressing lineage demonstrates cardiomyocyte plasticity during zebrafish heart regeneration. PMID: 29382818
    3. Regulatory evolution of Tbx5 and the origin of paired appendages, such as fins, is presented. PMID: 27503876
    4. a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility. PMID: 26525676
    5. Results show that cul4a but not cul4b is required for the expression of tbx5a, an essential transcription factor in heart and limb development. PMID: 25274780
    6. The tbx5 genes have essential roles in the establishment of cardiac laterality, dorsoventral retina axis organization and pectoral fin development. PMID: 24759614
    7. Despite similar spatio-temporal expression patterns, tbx5a and tbx5b have independent functions in heart and fin development. PMID: 23441045
    8. tbx5 knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis PMID: 22776023
    9. tbx5 deficiency evoked apoptosis, distributed on multiple organs corresponding to dysmorphogenesis with the shortage of promising maturation, in tbx5 knockdown zebrafish embryos PMID: 21982178
    10. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5, tbx20, and has2 in the heart PMID: 20306498
    11. Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate proepicardial organ development. PMID: 20413782
    12. Pdlim7/Tbx5 interactions affect the expression of Tbx5 target genes nppa and tbx2b at the atrio-ventricular boundary, and their domains of misexpression directly correlate with the identified valve defects. PMID: 19895804
    13. The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome. PMID: 12223419
    14. overexpression of hrT causes a significant downregulation of tbx5, indicating that one key role of hrT is to regulate the levels of tbx5 PMID: 12397116
    15. Tbx5, in addition to its role governing forelimb identity, is both necessary and sufficient for limb outgrowth; Tbx5 functions downstream of WNT signaling to regulate Fgf10, which, in turn, maintains Tbx5 expression during limb outgrowth. PMID: 12399308
    16. Sall gene family redundancy and tbx5 offer explanations for the similarity of individuals with Okihiro syndrome and Holt-Oram syndrome limb defects PMID: 16501170
    17. heart failure caused by the knockdown of tbx5 gene might result from the down-regulation of cardiac myogenesis genes PMID: 18661250
    18. redundant activities of Nkx2.5 and Nkx2.7 are required for cardiac morphogenesis, but Nkx2.7 plays a more critical function, regulating the expressions of tbx5 and tbx20 through the maturation stage PMID: 19158954
    19. the genetic interaction of Tbx5 and Mef2c is not only required for MYH6 expression but also essential for the early stages of heart development and survival PMID: 19204083

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Expressed in the dorsal optic cup of developing eye, pectoral fin buds and heart. At 31 hpf, when the pectoral fin buds have begun bulging outwards, restricted expression is detected throughout the mesenchyme of the early fin buds and these high levels of
  • 數據庫鏈接：

    KEGG: dre:30071

    STRING: 7955.ENSDARP00000033053

    UniGene: Dr.81302



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