在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Danio rerio Survival motor neuron protein 1 (smn1)

Recombinant Danio rerio Survival motor neuron protein 1 (smn1)

  • 中文名稱：
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào)：
    CSB-YP895248DIL
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào)：
    CSB-EP895248DIL
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào)：
    CSB-EP895248DIL-B
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào)：
    CSB-BP895248DIL
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào)：
    CSB-MP895248DIL
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    smn1; smn; Survival motor neuron protein 1
  • 種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-281
  • 氨基酸序列
    MANGAEDVVF CRGTGQSDDS DIWDDTALIK AYDKAVASFK NALKGEDGAT PQENDNPGKK RKNNKKNKSR KRCNAAPDKE WQVGDSCYAF WSEDGNLYTA TITSVDQEKG TCVVFYTDYG NEEEQNLSDL LTEPPDMDED ALKTANVKET ESSTEESDRS FTPQKSGHAK HKSKSNFPMG PPSWFPSFPP GPPPPPPHFK KMDGRRGEGP GPSFPGWPPM IPLGPPMIPP PPPMSPDFGE DDEALGSMLI SWYMSGYHTG YYMGLRQGRK EAAASKKSHR K
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites.
  • 基因功能參考文獻(xiàn)：
    1. we established that the additional supply of Smn protein in motoneurons is necessary for proper axonogenesis in a cell-autonomous manner PMID: 27273160
    2. In motor neurons, smn1 interacts with the RNA binding protein, HuD and regulates motoneuron development and function. PMID: 29061699
    3. our finding that elevation of Pgk1 levels or activity, via injection of Pgk1 mRNA or treatment with terazosin respectively, robustly ameliorated MN pathology in smn morphant zebrafish provides an initial demonstration that these pathways are amenable to therapeutic intervention. PMID: 28426667
    4. Reduction of Gemin2, unlike reduction of SMN, in zebrafish embryos does not directly cause motor axon outgrowth defects. PMID: 18000835
    5. SMN deficiency affects splicing and abundance of nrxn2a. This may explain the pre-synaptic defects at neuromuscular endplates in SMA pathophysiology. PMID: 24218366
    6. SMN is needed early in development of motoneuron dendrites and axons to develop normally and that this is essential for proper connectivity and movement. PMID: 23459934
    7. These results show that survival motor neuron functions in motor axon development and suggest that these early developmental defects may lead to subsequent motoneuron loss. PMID: 12952942
    8. Survival motor neuron has a novel function in motor neurons independent of small nuclear ribonucleoprotein (snRNP) biosynthesis. PMID: 17065443
    9. Since Gemin2 and SMN both function in snRNP biogenesis yet only SMN knockdown causes motor axon defects, these data are consistent with an additional role for SMN that is snRNP independent. PMID: 18000835
    10. Smn mutants in zebrafish survive to larval stages and exhibit presynaptic neuromuscular junction defects. PMID: 19592581

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    SMN family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dre:30432

    STRING: 7955.ENSDARP00000017636

    UniGene: Dr.75206



主站蜘蛛池模板： 国产精品亚洲а∨无码播放不卡 | 免费两性的视频网站 | 亚洲午夜高清国产拍| 亚洲大码熟女在线| 亚洲色成人网站www永久| 国产乱子夫妻xx黑人xyx真爽| 新狼窝色av性久久久久久| 在线 | 麻豆国产传媒61国产免费| 中文字幕v亚洲日本在线| 亚洲色欲色欲77777小说网站| 国产精品一区二区av交换| 少妇精品无码一区二区免费视频| 国产精品自产拍高潮在线观看| 熟妇人妻中文av无码| 国产高清卡1卡2卡3麻豆| 国产成人精品亚洲精品| 96国产xxxx免费视频| 国产成人精品午夜福利| 亚洲午夜私人影院在线观看| 免费做a爰片久久毛片a片下载| 色综合久久久久久久久五月| 国产免费艾彩sm调教视频 | 欧美成人精品 一区二区三区| 亚洲中文久久精品无码1 | 国产女人高潮叫床视频| 欧美亚洲日韩国产网站| 亚洲精品久久yy5099| 岛国无码av不卡一区二区| 思思99热久久精品在线6| 亚洲中文字幕无码久久2017 | ww欧日韩视频高清在线| 在线精品无码字幕无码av| 久久棈精品久久久久久噜噜 | 动漫av网站免费观看| 日韩新无码精品毛片| 少妇人妻陈艳和黑人教练| 特级做a爰片毛片免费看| 非洲黑人最猛性xxxx交| 男人扒开女人双腿猛进视频| 免费乱理伦片在线观看| 久久国产高潮流白浆免费观看|