在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Danio rerio Survival motor neuron protein 1 (smn1)

  • 中文名稱:
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào):
    CSB-YP895248DIL
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào):
    CSB-EP895248DIL
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào):
    CSB-EP895248DIL-B
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào):
    CSB-BP895248DIL
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    斑馬魚(yú)smn1重組蛋白
  • 貨號(hào):
    CSB-MP895248DIL
  • 說(shuō)明書(shū):
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    smn1; smn; Survival motor neuron protein 1
  • 種屬:
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-281
  • 氨基酸序列
    MANGAEDVVF CRGTGQSDDS DIWDDTALIK AYDKAVASFK NALKGEDGAT PQENDNPGKK RKNNKKNKSR KRCNAAPDKE WQVGDSCYAF WSEDGNLYTA TITSVDQEKG TCVVFYTDYG NEEEQNLSDL LTEPPDMDED ALKTANVKET ESSTEESDRS FTPQKSGHAK HKSKSNFPMG PPSWFPSFPP GPPPPPPHFK KMDGRRGEGP GPSFPGWPPM IPLGPPMIPP PPPMSPDFGE DDEALGSMLI SWYMSGYHTG YYMGLRQGRK EAAASKKSHR K
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites.
  • 基因功能參考文獻(xiàn):
    1. we established that the additional supply of Smn protein in motoneurons is necessary for proper axonogenesis in a cell-autonomous manner PMID: 27273160
    2. In motor neurons, smn1 interacts with the RNA binding protein, HuD and regulates motoneuron development and function. PMID: 29061699
    3. our finding that elevation of Pgk1 levels or activity, via injection of Pgk1 mRNA or treatment with terazosin respectively, robustly ameliorated MN pathology in smn morphant zebrafish provides an initial demonstration that these pathways are amenable to therapeutic intervention. PMID: 28426667
    4. Reduction of Gemin2, unlike reduction of SMN, in zebrafish embryos does not directly cause motor axon outgrowth defects. PMID: 18000835
    5. SMN deficiency affects splicing and abundance of nrxn2a. This may explain the pre-synaptic defects at neuromuscular endplates in SMA pathophysiology. PMID: 24218366
    6. SMN is needed early in development of motoneuron dendrites and axons to develop normally and that this is essential for proper connectivity and movement. PMID: 23459934
    7. These results show that survival motor neuron functions in motor axon development and suggest that these early developmental defects may lead to subsequent motoneuron loss. PMID: 12952942
    8. Survival motor neuron has a novel function in motor neurons independent of small nuclear ribonucleoprotein (snRNP) biosynthesis. PMID: 17065443
    9. Since Gemin2 and SMN both function in snRNP biogenesis yet only SMN knockdown causes motor axon defects, these data are consistent with an additional role for SMN that is snRNP independent. PMID: 18000835
    10. Smn mutants in zebrafish survive to larval stages and exhibit presynaptic neuromuscular junction defects. PMID: 19592581

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族:
    SMN family
  • 數(shù)據(jù)庫(kù)鏈接:

    KEGG: dre:30432

    STRING: 7955.ENSDARP00000017636

    UniGene: Dr.75206



主站蜘蛛池模板: 午夜天堂精品久久久久| 国产精品对白交换视频| 欧美精品乱码99久久蜜桃| 国产精品色无码av在线观看| 男女野外做爰全过程69影院| 亚洲国产午夜精华无码福利| 国产强奷在线播放免费 | 亚洲精品乱拍国产一区二区三区| 免费的污污的网站在线观看| 浪潮av色综合久久天堂| 国产精品igao视频| 东北少妇不戴套对白第一次 | 熟妇的奶头又大又粗视频| 亚洲国产精品第一区二区| 国产精品自在欧美一区| 人与动人物xxxx毛片人与狍| 人人人插人人费| 成熟老妇女毛茸茸的做性| 免费网站看sm调教视频| 狠狠色综合激情丁香五月| 在线观看欧美一区二区三区| 亚洲人成无码网www电影榴莲| 国产片av国语在线观麻豆| 18禁超污无遮挡无码免费动态图| 精品人人妻人人澡人人爽牛牛| 又黄又爽又无遮挡免费的网站| 日日碰狠狠躁久久躁2023| 国产成人亚洲综合网站小说| 国产aⅴ精品一区二区三区| 蜜桃视频无码区在线观看| 中文字幕一区二区三区日韩精品 | 2021少妇久久久久久久久久| 朝鲜女子内射杂交bbw| 免费看成人aa片无码视频吃奶| 97久久国产亚洲精品超碰热| 久久久久日韩精品免费观看| 国产美女露脸口爆吞精| 免费观看一区二区三区| 久久久久亚洲精品无码网址| 亚洲一二三四2021不卡| 正在播放熟妇群老熟妇456|