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  4. Recombinant Chicken Repulsive guidance molecule A (RGMA)

Recombinant Chicken Repulsive guidance molecule A (RGMA)

  • 中文名稱：
    雞RGMA重組蛋白
  • 貨號：
    CSB-YP818289CH
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    雞RGMA重組蛋白
  • 貨號：
    CSB-EP818289CH
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    雞RGMA重組蛋白
  • 貨號：
    CSB-EP818289CH-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    雞RGMA重組蛋白
  • 貨號：
    CSB-BP818289CH
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    雞RGMA重組蛋白
  • 貨號：
    CSB-MP818289CH
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    RGMA; RGM; Repulsive guidance molecule A
  • 種屬：
    Gallus gallus (Chicken)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    150-404
  • 氨基酸序列
    P HLRTFTDTFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSS ATATSKLTII FKSFQECVEQ KVYQAEMDEL PAAFADGSKN GGDKHGANSL KITEKVSGQH IEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC PLNQQIDFQT FRLAQAAEGR ARRKGPSLPA PPEAFTYESA TAKCREKLPV EDLYFQSCVF DLLTTGDVNF MLAAYYAFED VKMLHSNKDK LHLYERTRAL APGN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.
  • 基因功能參考文獻：
    1. C-RGMa activates the Leukemia-associated RhoGEF (LARG)/Rho/Rock pathway to block axonal growth. PMID: 26292756
    2. RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis. PMID: 23073896
    3. Repulsive guidance molecule is mediated by the action of neogenin. PMID: 15258590
    4. Repulsive guidance molecule regulates neuronal survival. PMID: 15258591
    5. RGMa overexpression promotes neuronal differentiation, whereas RGMa small interference RNA represses it. PMID: 16738252
    6. Repulsive guidance molecule A expression on retinal axons is a major determinant of topographic targeting in the retino-tectal projection and in the retina. PMID: 18280178

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Repulsive guidance molecule (RGM) family
  • 數據庫鏈接：

    KEGG: gga:395214

    STRING: 9031.ENSGALP00000011271

    UniGene: Gga.117



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