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  4. Recombinant Chicken Fibroblast growth factor receptor 1 (FGFR1), partial

Recombinant Chicken Fibroblast growth factor receptor 1 (FGFR1), partial

  • 中文名稱：
    雞FGFR1重組蛋白
  • 貨號：
    CSB-YP008642CH1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    雞FGFR1重組蛋白
  • 貨號：
    CSB-EP008642CH1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    雞FGFR1重組蛋白
  • 貨號：
    CSB-EP008642CH1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    雞FGFR1重組蛋白
  • 貨號：
    CSB-BP008642CH1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    雞FGFR1重組蛋白
  • 貨號：
    CSB-MP008642CH1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    FGFR1; CEK1; Fibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; Basic fibroblast growth factor receptor 1; Tyrosine kinase receptor CEK1
  • 種屬：
    Gallus gallus (Chicken)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation.
  • 基因功能參考文獻：
    1. FGFR1 promoter activity in skeletal muscle cells is repressed by E2F4. PMID: 15580623
    2. BTEB1 activated the FGFR1 promoter via interaction with the Sp1-like binding site located at -59 bp within the FGFR1 promoter. PMID: 20554758
    3. results indicate that AP-2 alpha is a transcriptional repressor of FGFR1 gene expression during skeletal myogenesis PMID: 19699737
    4. a neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development PMID: 19666467
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily
  • 數據庫鏈接：

    KEGG: gga:396516

    UniGene: Gga.870



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