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  4. Recombinant Bovine Oxytocin-neurophysin 1 (OXT)

Recombinant Bovine Oxytocin-neurophysin 1 (OXT)

  • 中文名稱：
    牛OXT重組蛋白
  • 貨號：
    CSB-YP017315BO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛OXT重組蛋白
  • 貨號：
    CSB-EP017315BO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    牛OXT重組蛋白
  • 貨號：
    CSB-EP017315BO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛OXT重組蛋白
  • 貨號：
    CSB-BP017315BO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛OXT重組蛋白
  • 貨號：
    CSB-MP017315BO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    OXT; Oxytocin-neurophysin 1; OT-NPI) [Cleaved into: Oxytocin; Ocytocin); Neurophysin 1]
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    32-125
  • 氨基酸序列
    AVLDLDVRT CLPCGPGGKG RCFGPSICCG DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA AGICCSPDGC HEDPACDPEA AFSQH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR).
  • 基因功能參考文獻：
    1. Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system. PMID: 28163019
    2. Oxytocin (OT) mRNA and protein levels were lower in the corpus luteum of pregnancy than in the corpus luteum of the estrous cycle. PMID: 24856470
    3. These data suggest that cortisol affects oxytocin synthesis and secretion in bovine ovarian cells, by acting on the expression of key genes, that may impair ovary PMID: 23971190
    4. Binding of oestrogen receptor-related receptor alpha to the oxytocin promoter binding site is demonstrated, suggesting the involvement of this receptor in oestrogen-dependent up-regulation. PMID: 15842231
    5. data demonstrate an effect of dimerization in the unliganded state on the hormone-binding site involving residues that interact with hormone residue 2, & identify Ser25 & Ile26 as likely intermediaries between the sites of dimerization & hormone binding PMID: 16128578
    6. loop status modulates dimerization via long-range effects on neurophysin conformation involving neighboring Phe22 as a key intermediary PMID: 17192588
    7. Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 and PGF(2alpha) within the corpus luteum. PMID: 17287495

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Vasopressin/oxytocin family
  • 數據庫鏈接：

    KEGG: bta:280888

    STRING: 9913.ENSBTAP00000010554

    UniGene: Bt.183



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