在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Bovine Oxidized low-density lipoprotein receptor 1 (OLR1), partial

Recombinant Bovine Oxidized low-density lipoprotein receptor 1 (OLR1), partial

  • 中文名稱：
    牛OLR1重組蛋白
  • 貨號(hào)：
    CSB-YP016331BO1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛OLR1重組蛋白
  • 貨號(hào)：
    CSB-EP016331BO1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    牛OLR1重組蛋白
  • 貨號(hào)：
    CSB-EP016331BO1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛OLR1重組蛋白
  • 貨號(hào)：
    CSB-BP016331BO1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛OLR1重組蛋白
  • 貨號(hào)：
    CSB-MP016331BO1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    OLR1; LOX1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; bLOX-1; Lectin-type oxidized LDL receptor 1
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
  • 基因功能參考文獻(xiàn)：
    1. Endothelial LOX-1 overexpression in an atherosclerosis-prone LDL receptor knockout mice impairs endothelial function, proving its importance in the development of atherosclerosis. PMID: 29096854
    2. bta-miR-370 has a negative regulatory effect on the OLR1 gene at both the gene and protein expression levels and has a role in lipid metabolism in bovine adipocytes PMID: 28294375
    3. Overexpression of LOX-1 leads to the attenuation of protective autophagy response in aortic endothelial cells. PMID: 25703423
    4. These results imply that the 3' UTR SNP of the OLR1 gene is a strong candidate marker for selection in cattle breeding programs. PMID: 23910552
    5. Our data indicate that blocking the LOX-1 receptor signal pathway might be a promising way to improve steroid hormone concentrations in metabolically highly active female mammals PMID: 24115745
    6. In the present study, we show that inhibition of LOX-1 leads to a rearrangement of ceramide from the basal membrane toward the Golgi apparatus PMID: 24710763
    7. The downregulation of eNOS by ox-low-density lipoprotein, as driven by LOX-1-mediated endoplasmic stress, is associated with the PI3K-Akt-eNOS signaling pathway. PMID: 24085225
    8. 3'-UTR SNP assoicated with milk composition traits and somatic cell score PMID: 22365237
    9. Disruption of lipid packing of cholesterol-rich membrane domains plays a key role in oxidized low-density lipoprotein (oxLDL)-induced changes in endothelial biomechanics. PMID: 20410437
    10. Oxidized low-density lipoprotein receptor (OLR1) single nucleotide polymorphism haplotype is associated with milk fat yield and fat percentage PMID: 16606746
    11. synergistic effects of cyclic tensile stretch load and ox-LDL on cell viability and proteoglycan synthesis in chondrocytes, which may be mediated through enhanced expression of LOX-1 PMID: 16795046
    12. Upregulates VEGF expression in articular cartilage, at least in part, through activation of PPAR-gamma. PMID: 16904074
    13. Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. PMID: 19150883
    14. ox-LDL binding to LOX-1 induces stress-induced senescence of chondrocytes and suppression of telomerase activity. Oxidized LDL may play an important role in the pathogenesis of osteoarthritis by inducing chondrocyte senescence. PMID: 19790061

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted.
  • 組織特異性：
    Highly expressed in endothelial cells, aortic intima and lung. Expressed at low level in other tissues.
  • 數(shù)據(jù)庫鏈接：

    KEGG: bta:281368

    STRING: 9913.ENSBTAP00000005975

    UniGene: Bt.367



主站蜘蛛池模板： 少妇特殊按摩高潮惨叫无码| 97久久精品人妻人人搡人人玩| 国产午国产午夜精华 免费| 国产av人人夜夜澡人人爽| 成人网站色52色在线观看| 国产三级精品三级在线专区| 四虎影视在线永久免费观看 | 婷婷综合缴情亚洲狠狠| 国产午夜福利伦理300| 女人被黑人狂躁c到高潮小说| 国产精品国产三级国产aⅴ下载 | 日本亚洲vr欧美不卡高清专区| 亚洲国产日韩a在线播放| 国精产品999国精产品官网| 亚洲一区av无码少妇电影| 日本国产网曝视频在线观看 | 777米奇色狠狠888俺也去乱| 国产午夜成人免费看片| 精品国产三级a在线观看| 免费看国产精品3a黄的视频| 欧美黑人xxxx性高清版| 亚洲欧美成人一区二区三区| 人人做人人妻人人精| 在线天堂资源www在线污| 800av凹凸视频在线观看| 亚洲午夜久久久影院伊人| 亚洲最大的成人网站| 男女啪啪抽搐呻吟高潮动态图| 国产又爽又大又黄a片| 麻豆国产人妻欲求不满谁演的| 亚洲乱码日产一区三区| 亚洲一区精品无码色成人| 野外做受三级视频| 精品久久久久久久久久久国产字幕 | 午夜激成人免费视频在线观看| a片免费视频在线观看| 天天摸日日摸爽爽狠狠| 九九热爱视频精品视频16| 欧美牲交a欧美牲交| 羞羞色男人的天堂| 男女猛烈无遮挡免费视频app|