在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Bovine Microtubule-associated protein tau (MAPT)

  • 中文名稱:
    牛MAPT重組蛋白
  • 貨號:
    CSB-YP013481BO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    牛MAPT重組蛋白
  • 貨號:
    CSB-EP013481BO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    牛MAPT重組蛋白
  • 貨號:
    CSB-EP013481BO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    牛MAPT重組蛋白
  • 貨號:
    CSB-BP013481BO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    牛MAPT重組蛋白
  • 貨號:
    CSB-MP013481BO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    MAPT; TAU; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
  • 種屬:
    Bos taurus (Bovine)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-448
  • 氨基酸序列
    AEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT AEDATAPLVD EGAPGEQAAA QAPAEIPEGT AAEEAGIGDT SNLEDQAAGH VTQARMVSKG KDGTGPDDKK TKGADGKPGT KIATPRGAAP PGQKGQANAT RIPAKTTPTP KTSPATMQVQ KKPPPAGAKS ERGESGKSGD RSGYSSPGSP GTPGSRSRTP SLPTPPTREP KKVAVVRTPP KSPSAAKSRL QAAPGPMPDL KNVKSKIGST ENLKHQPGGG KVQIINKKLD LSNVQSKCGS KDNIKHVPGG GSVQIVYKPV DLSKVTSKCG SLGNIHHKPG GGQVEVKSEK LDFKDRVQSK IGSLDNITHV PGGGNKKIET HKLTFRENAK AKTDHGAEIV YKSPVVSGDT SPRHLSNVSS TGSIDMVDSP QLATLADEVS ASLAKQGL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
  • 基因功能參考文獻:
    1. the energy landscape of Tau-mediated, GTP-dependent 'active' microtubule bundles, is reported. PMID: 27452526
    2. Findings suggest that the endothelin-1-induced down-regulation of NaV1.7 (SCN9A) diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau. PMID: 23434582
    3. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn. PMID: 22403409
    4. show that cathepsin D cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP are involved in the pathogenesis of Alzheimer's disease PMID: 21267651
    5. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation PMID: 20470771
    6. We conclude that GSK3beta phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially. PMID: 16519507
    7. hyperphosphorylated-tau specific local phosphorylation patterns at Thr212/Ser214 and Thr231/Ser235 using monoclonal antibodies (mAb) generated against correspondingly modified peptides PMID: 16781671

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cytoplasm. Cell projection, dendrite. Secreted. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
  • 組織特異性:
    Expressed in neurons.
  • 數據庫鏈接:


主站蜘蛛池模板: 国产午夜伦鲁鲁| 国产日产韩国精品视频| аⅴ天堂中文在线网| 国产在线一区二区av视频| 成人无码av一区二区三区| 亚洲午夜福利院在线观看| 色偷偷一区二区无码视频| 亚洲中文字幕无码中字| 少妇精品导航| 日日天日日夜日日摸| 中文在线天堂а√在线| 波多野结衣av无码久久一区| 成人无码www在线看免费| 亚洲 欧洲 日韩 综合在线| 亚洲6080yy久久无码产自国产| 精品无码一区二区三区在线| 乱码午夜-极国产极内射| 丰满人妻被黑人中出849| 国产白嫩护士被弄高潮| 国产伦精品一区二区三区免费迷 | 无遮挡裸体免费视频尤物| 丝袜老师办公室里做好紧好爽 | 国产99视频精品免费视频36| 色偷偷亚洲第一成人综合网址| 亚洲精品99久久久久中文字幕| 婷婷久久综合九色综合| 狠狠色狠狠色五月激情| 成人免费无码大片a毛片抽搐| 蜜臀av人妻国产精品建身房| 中文无码字幕中文有码字幕| 国产女厕所盗摄老师厕所嘘嘘| 大肉大捧一进一出好爽视色大师| 国产人妻人伦精品1国产| 好男人www社区视频在线资源 | av天堂久久精品影音先锋| 亚洲国产精品毛片av不卡在线| 三叶草欧洲码在线| 免费视频成人片在线观看| 国产激情高中生呻吟视频 | 真正免费毛片在线播放| 久久国产精品99国产精|