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  4. Recombinant Bovine Keratin, type I cytoskeletal 17 (KRT17)

Recombinant Bovine Keratin, type I cytoskeletal 17 (KRT17)

  • 中文名稱：
    牛KRT17重組蛋白
  • 貨號：
    CSB-YP012516BO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛KRT17重組蛋白
  • 貨號：
    CSB-EP012516BO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛KRT17重組蛋白
  • 貨號：
    CSB-BP012516BO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛KRT17重組蛋白
  • 貨號：
    CSB-MP012516BO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    KRT17; Keratin; type I cytoskeletal 17; Cytokeratin-17; CK-17; Keratin-17; K17
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-441
  • 氨基酸序列
    MTTTIRHFSS GSIKGSSGLA GGSSRSCRVS GSLGGGSCRL GSAGGLGSGL GGSSYSSCYS FGSGGGYGSG GYVSGGYGGG FGGVDGLLVG GEKATMQNLN DRLASYLDKV RALEEANTEL ELKIRDWYQK QAPGPAPDYS SYFKTIEDLR NKIHTATVDN ANLLLQIDNA RLAADDFRTK FETEQALRVS VEADINGLRR VLDELTLARA DLEMQIENLK EELAYLRKNH EEEMKALRGQ VGGEINVEMD AAPGVDLSRI LNEMRDQYEK MAEKNRKDAE DWFFSKTEEL NREVATNSEL VQSGKSEISE LRRTLQALEI ELQSQLSMKA SLEGSLAETE NRYCMQLSQI QGLIGSVEEQ LAQLRCEMEQ QNQEYKILLD VKTRLEQEIA TYRRLLEGED AHLTQYKTKE PVTTRQVRTI VEEVQDGRVI SSREQVHQTS H
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Intermediate filament family
  • 數據庫鏈接：


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