在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Bovine G protein-coupled receptor kinase 5 (GRK5), partial

Recombinant Bovine G protein-coupled receptor kinase 5 (GRK5), partial

  • 中文名稱：
    牛GRK5重組蛋白
  • 貨號：
    CSB-YP009926BO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛GRK5重組蛋白
  • 貨號：
    CSB-EP009926BO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    牛GRK5重組蛋白
  • 貨號：
    CSB-EP009926BO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛GRK5重組蛋白
  • 貨號：
    CSB-BP009926BO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛GRK5重組蛋白
  • 貨號：
    CSB-MP009926BO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    GRK5; GPRK5G protein-coupled receptor kinase 5; EC 2.7.11.16; G protein-coupled receptor kinase GRK5
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors (Beta-2 adrenergic receptor), muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
  • 基因功能參考文獻：
    1. GRK5, acting in a kinase independent manner, is a facilitator of NFAT activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription. PMID: 25332207
    2. potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway PMID: 22952844
    3. GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity. PMID: 19008357
  • 亞細胞定位：
    Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
  • 組織特異性：
    Highest levels in lung, heart, retina, lingual epithelium. Very little in brain, liver, kidney.
  • 數據庫鏈接：


主站蜘蛛池模板： 中文有码亚洲制服av片| 国产又色又爽又黄刺激在线视频| 一本色道久久综合亚洲精品| 乱熟女高潮一区二区在线| 性人久久网av| 99久无码中文字幕一本久道| 92国产精品午夜免费福利视频| 性欧美疯狂xxxxbbbb| 电影内射视频免费观看| 一本大道无码av天堂| 18禁成年无码免费网站| 国产日韩在线视看第一页 | 久久人妻av一区二区软件| 无码中文字幕色专区| 无码尹人久久相蕉无码| 久久亚洲精品成人无码网站夜色| 午夜成人性刺激免费视频| 日韩av片无码一区二区不卡电影| 国产精品a无线| 青春草在线视频免费观看| 成人无码免费视频在线播| 欧美黑人性暴力猛交喷水| 成人亚洲国产精品一区不卡| аⅴ资源天堂资源库在线| 国产精品亚洲专区无码牛牛| 亚洲视频日本有码中文| 噜噜噜av久久| 99久久久无码国产精品免费砚床| 久久人人爽人人爽人人片av不| 亚洲大尺度无码无码专线一区 | 成人免费毛片aaaaaa片| 天天噜日日噜狠狠噜免费| 18禁真人抽搐一进一出在线| 亚洲国产欧美在线观看片不卡| 野花社区在线观看视频| 欧洲熟妇性色黄| 国产α片免费观看在线人| 国产成人年无码av片在线观看| 国产成人精品亚洲777人妖| 欧美内射rape视频| 日韩欧美中文字幕在线三区|