在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Bovine Folliculin (FLCN), partial

Recombinant Bovine Folliculin (FLCN), partial

  • 中文名稱：
    牛FLCN重組蛋白
  • 貨號：
    CSB-YP008711BO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛FLCN重組蛋白
  • 貨號：
    CSB-EP008711BO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    牛FLCN重組蛋白
  • 貨號：
    CSB-EP008711BO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛FLCN重組蛋白
  • 貨號：
    CSB-BP008711BO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛FLCN重組蛋白
  • 貨號：
    CSB-MP008711BO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    FLCNFolliculin
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3. Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RRAGC/RagC or RRAGD/RagD, promoting the conversion to the GDP-bound state of RRAGC/RagC or RRAGD/RagD, and thereby activating the kinase activity of mTORC1. The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients. Acts as a key component for mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1. In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3. Upon amino acid restimulation, RRAGA/RagA (or RRAGB/RagB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3. Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3. Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling. Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3. In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation. Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy. Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34.
  • 亞細胞定位：
    Lysosome membrane. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus.
  • 蛋白家族：
    Folliculin family
  • 數據庫鏈接：


主站蜘蛛池模板： 好紧好爽免费午夜视频| 精品无码中文视频在线观看| 国内大量揄拍人妻精品視頻| 亚洲视频无码高清在线| 亚洲精品网站在线观看你懂的| 一区二区在线 | 欧洲| 亚洲中文字幕无码一久久区| 无码人妻丰满熟妇区五十路在线| 13小箩利洗澡无码视频网站| 大白肥妇bbvbbw高潮| 日韩人妻熟女中文字幕a美景之屋 高h纯肉无码视频在线观看 | 强行从后面挺进人妻| 国产一区二区三区小说| 国产精品一区二区久久精品| 亚洲人成77在线播放网站| 国产成人小说视频在线观看| 乱妇乱女熟妇熟女网站| 国产在线一卡2卡三卡4卡免费| 99re久久热在这里精品| 日本三级香港三级三级人!妇久 | 欧洲多毛裸体xxxxx| 女高中生第一次破苞av| 欧美自拍另类欧美综合图片区| 乱色精品无码一区二区国产盗| 熟女人妻aⅴ一区二区三区麻豆| 婷婷五月综合国产激情| 色妞www精品视频| 无码人妻精品中文字幕| 侵犯强奷高清无码| 日韩少妇人妻vs中文字幕| 成人欧美一区二区三区黑人| 久久www免费人成人片| 国产精品18久久久久久欧美| 欧美成a人片在线观看久| 在线视频夫妻内射| 天堂网www天堂资源网| 久久人人爽人人爽人人片av高清| 亚洲男女羞羞无遮挡久久丫| 99久久无码一区人妻a片潘金莲| 国产一区二区三区无码免费| 玩弄少妇高潮ⅹxxxyw|