在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Bovine Angiopoietin-1 receptor (TEK), partial

  • 中文名稱(chēng):
    牛TEK重組蛋白
  • 貨號(hào):
    CSB-YP023375BO
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱(chēng):
    牛TEK重組蛋白
  • 貨號(hào):
    CSB-EP023375BO
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱(chēng):
    牛TEK重組蛋白
  • 貨號(hào):
    CSB-EP023375BO-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱(chēng):
    牛TEK重組蛋白
  • 貨號(hào):
    CSB-BP023375BO
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱(chēng):
    牛TEK重組蛋白
  • 貨號(hào):
    CSB-MP023375BO
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    TEK; TIE-2; TIE2; Angiopoietin-1 receptor; EC 2.7.10.1; Endothelial tyrosine kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TIE-2; CD antigen CD202b
  • 種屬:
    Bos taurus (Bovine)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1.
  • 基因功能參考文獻(xiàn):
    1. Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. PMID: 27216150
  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, Tie subfamily
  • 組織特異性:
    Specifically expressed in developing vascular endothelial cells.
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 人人妻人人妻人人人人妻人人| 538在线精品视频| 人妻久久久一区二区三区| 骚虎视频在线观看| 色综合欧美亚洲国产| 人妻熟女一区二区aⅴ水野朝阳| 国产精品午夜小视频观看| 国产精品白丝喷水在线观看| 国产精品久久精品国产| 97在线成人国产在线视频| 亚洲综合无码一区二区痴汉| 国产人妻精品一区二区三首| 丰满岳妇乱一区二区三区| 欧美 变态 另类 人妖| 久久精品国产99国产精偷| 蜜臀色欲av在线播放国产日韩| 国产精品久久自在自线不| 精品乱人伦一区二区三区 | 亚洲精品成人片在线播放| 国产黄网永久免费视频大全| 国产超碰人人做人人爽av| 国语自产拍无码精品视频在线| 欧美噜噜久久久xxx| 荡女精品导航| 国产亚洲精品久久久久秋霞不卡| 韩国精品久久久久久无码| 永久免费无码av网站在线观看 | 国产色a在线观看| 国产对白老熟女正在播放| 亚洲国产精品尤物yw在线| 亚洲色成人一区二区三区| 欧美日韩一区二区综合| 欧美国产国产综合视频| 国产乱子伦三级在线播放| 97色偷偷色噜噜男人的天堂| av无码免费永久在线观看| 亚洲国产无线乱码在线观看| 成人无码免费视频在线播| 国产成人精品午夜福利不卡 | 国产国拍精品av在线观看按摩| 久久一日本道色综合久久|