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  4. Recombinant Bovine Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3)

Recombinant Bovine Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3)

  • 中文名稱：
    Recombinant Bovine Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3(ALKBH3)
  • 貨號：
    CSB-YP653462BO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Bovine Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3(ALKBH3)
  • 貨號：
    CSB-EP653462BO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Bovine Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3(ALKBH3)
  • 貨號：
    CSB-EP653462BO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Bovine Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3(ALKBH3)
  • 貨號：
    CSB-BP653462BO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Bovine Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3(ALKBH3)
  • 貨號：
    CSB-MP653462BO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ALKBH3
  • Uniprot No.：
  • 別名：
    ALKBH3; ABH3Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; EC 1.14.11.54; Alkylated DNA repair protein alkB homolog 3
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-286
  • 氨基酸序列
    MEDKRRRARV QGAWAGPAKS QATAQPAPTA ENNLQQRPGK AWMNKEQHLS DRQFVFKEPQ EGVRRAPEPR VIEKEGVYEI SMSPTGISRV CLCPGFVDLK EADSVFEQLC RDVPWKQRTG IRDDVTYQQP RLTAWYGELP YTYSRITMEP NPHWHPVLLM LKNQIEENTG HSFNSLLCNL YRNEKDSVDW HSDDEPSLGR CPIIASLSFG ATRMFEMRKK PPPEDNGDYT YVERVKIPLD HGTLLIMEGA TQADWQHRVP KEYHSREPRI NLTFRTVYPD PRGAHW
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron.
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    AlkB family
  • 數據庫鏈接：


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