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  4. Phospho-GYS1 (S641) Recombinant Monoclonal Antibody

Phospho-GYS1 (S641) Recombinant Monoclonal Antibody

  • 中文名稱：
    磷酸化-GYS1 (S641)重組抗體
  • 貨號：
    CSB-RA010078A641phHU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in Hela whole cell lysate,HepG2 whole cell lysate(treated with Calyculin A or EGF)
      All lanes Phospho-GYS1 antibody at 1.12μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 85 KDa
      Observed band size: 85 KDa
    • Immunofluorescence staining of HepG2 cells with CSB-RA010078A641phHU at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
  • 其他：

產品詳情

  • 產品描述：
    Phospho-GYS1 (S641) Recombinant Monoclonal Antibody（Code: CSB-RA010078A641phHU）是一款高特異性抗體，靶向糖原合成酶1（GYS1）第641位絲氨酸磷酸化修飾位點。GYS1是糖原合成的關鍵限速酶，其活性通過S641等位點的磷酸化受到精確調控，這一修飾可抑制酶活性，進而影響細胞能量代謝穩態，在糖尿病、腫瘤等疾病的代謝重編程研究中具有重要意義。該抗體經ELISA、Western Blot（WB）及免疫熒光（IF）等多平臺驗證，可特異性識別內源性磷酸化GYS1蛋白，推薦稀釋度為WB 1:500-1:5000、IF 1:20-1:200，批次間一致性優異。適用于研究能量代謝調控機制、糖原合成通路異常相關疾病模型及藥物干預下的磷酸化動態變化，為探索細胞葡萄糖代謝、胰島素信號傳導及病理狀態下代謝適應性改變提供可靠工具。本產品僅用于科學研究，不適用于臨床診斷或其他用途。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Glycogen [starch] synthase antibody; Glycogen synthase 1 (muscle) antibody; Glycogen synthase 1 antibody; GSY antibody; GYS antibody; Gys1 antibody; GYS1_HUMAN antibody; muscle antibody
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human Phospho-GYS1 (S641)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1D1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
  • 基因功能參考文獻：
    1. Insulin-stimulated glycogen synthase (GS) activity was completely ablated during hyperinsulinemic hypoglycemia, and catecholamine signaling via cAMP-dependent protein kinase (PKA) and phosphorylation of inhibiting sites on GS all increased. PMID: 28596236
    2. Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia PMID: 25487600
    3. over-expression of muscle glycogen synthase (MGS)was detected in diabetic human kidney PMID: 25371328
    4. High glycogen synthase 1 expression is associated with myeloid leukemia. PMID: 25703587
    5. Data suggest that although COOH-terminal dephosphorylation is likely necessary for GS activation, protein kinase Akt-2- (Akt2)-dependent NH2-terminal dephosphorylation is site for "fine-tuning" insulin-mediated GS activation in skeletal muscle. PMID: 23321478
    6. Allosteric regulation and the relationship between phosphorylation and the kinetics of glycogen synthase. [Review] PMID: 23134486
    7. The present findings demonstrate that physical inactivity-induced insulin resistance in muscle is associated with lower content/activity of key proteins in glucose transport/phosphorylation and storage. PMID: 22403297
    8. Exercise unmaskd the effect associated with the GYS1 polymorphism, rendering carriers of this allele less susceptible to the protective effect of exercise on the risk of cardiovascular mortality. PMID: 17356695
    9. the M416V polymorphism of glycogen synthase 1 gene is not associated with insulin resistance in type 2 diabetes PMID: 12870167
    10. Phosphorylation at site 2 in the elderly and at site 3a + 3b in young twins had a genetic component. PMID: 15855312
    11. no nuclear export signal was identified in the sequence of the protein, the region comprising amino acids 555-633, which has an Arg-rich cluster involved in the allosteric activation is crucial for its nuclear concentration and aggregation. PMID: 15955076
    12. 3 siblings were identified with profound muscle glycogen deficiency and homozygous stop mutations in GYS1 PMID: 17928598
    13. Pioglitazone treatment improved insulin-stimulated glucose metabolism and glycogen synthase activity in PCOS. PMID: 18544618
    14. After overnight low muscle glycogen level and/or in response to exhausting exercise-induced glycogenolysis, GSY is associated with spherical structures at the I-band of sarcomeres. PMID: 19339242
    15. Dysregulation of glycogen synthase phosphorylation plays a major role in impaired insulin regulation of GS in obesity and type 2 diabetes mellitus. PMID: 19837931

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  • 相關疾病：
    Muscle glycogen storage disease 0 (GSD0b)
  • 蛋白家族：
    Glycosyltransferase 3 family
  • 數據庫鏈接：

    HGNC: 4706

    OMIM: 138570

    KEGG: hsa:2997

    STRING: 9606.ENSP00000317904

    UniGene: Hs.386225



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