在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-GYS1 (S645) Antibody

  • 中文名稱:
    磷酸化-GYS1 (S645)兔多克隆抗體
  • 貨號:
    CSB-PA009063
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293 cells using Phospho-Glycogen Synthase 1 (S645) Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Glycogen [starch] synthase antibody; Glycogen synthase 1 (muscle) antibody; Glycogen synthase 1 antibody; GSY antibody; GYS antibody; Gys1 antibody; GYS1_HUMAN antibody; muscle antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human Glycogen Synthase 1 around the phosphorylation site of S645.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
  • 基因功能參考文獻:
    1. Insulin-stimulated glycogen synthase (GS) activity was completely ablated during hyperinsulinemic hypoglycemia, and catecholamine signaling via cAMP-dependent protein kinase (PKA) and phosphorylation of inhibiting sites on GS all increased. PMID: 28596236
    2. Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia PMID: 25487600
    3. over-expression of muscle glycogen synthase (MGS)was detected in diabetic human kidney PMID: 25371328
    4. High glycogen synthase 1 expression is associated with myeloid leukemia. PMID: 25703587
    5. Data suggest that although COOH-terminal dephosphorylation is likely necessary for GS activation, protein kinase Akt-2- (Akt2)-dependent NH2-terminal dephosphorylation is site for "fine-tuning" insulin-mediated GS activation in skeletal muscle. PMID: 23321478
    6. Allosteric regulation and the relationship between phosphorylation and the kinetics of glycogen synthase. [Review] PMID: 23134486
    7. The present findings demonstrate that physical inactivity-induced insulin resistance in muscle is associated with lower content/activity of key proteins in glucose transport/phosphorylation and storage. PMID: 22403297
    8. Exercise unmaskd the effect associated with the GYS1 polymorphism, rendering carriers of this allele less susceptible to the protective effect of exercise on the risk of cardiovascular mortality. PMID: 17356695
    9. the M416V polymorphism of glycogen synthase 1 gene is not associated with insulin resistance in type 2 diabetes PMID: 12870167
    10. Phosphorylation at site 2 in the elderly and at site 3a + 3b in young twins had a genetic component. PMID: 15855312
    11. no nuclear export signal was identified in the sequence of the protein, the region comprising amino acids 555-633, which has an Arg-rich cluster involved in the allosteric activation is crucial for its nuclear concentration and aggregation. PMID: 15955076
    12. 3 siblings were identified with profound muscle glycogen deficiency and homozygous stop mutations in GYS1 PMID: 17928598
    13. Pioglitazone treatment improved insulin-stimulated glucose metabolism and glycogen synthase activity in PCOS. PMID: 18544618
    14. After overnight low muscle glycogen level and/or in response to exhausting exercise-induced glycogenolysis, GSY is associated with spherical structures at the I-band of sarcomeres. PMID: 19339242
    15. Dysregulation of glycogen synthase phosphorylation plays a major role in impaired insulin regulation of GS in obesity and type 2 diabetes mellitus. PMID: 19837931

    顯示更多

    收起更多

  • 相關疾病:
    Muscle glycogen storage disease 0 (GSD0b)
  • 蛋白家族:
    Glycosyltransferase 3 family
  • 數據庫鏈接:

    HGNC: 4706

    OMIM: 138570

    KEGG: hsa:2997

    STRING: 9606.ENSP00000317904

    UniGene: Hs.386225



主站蜘蛛池模板: 天码人妻一区二区三区| 日本熟妇色高清免费视频| a v 在线视频 亚洲免费| 欧美特黄特色三级视频在线观看| 国产成人a无码短视频| 国产精品视频一区二区噜噜| 久久亚洲私人国产精品| 国产一区二区三区在线蜜桃| 亚洲国产欧美国产综合久久 | 成年免费视频黄网站在线观看| 人妻三级日本香港三级极| 亚洲精品国产自在现线最新| 三级男人添奶爽爽爽视频| 无限看片在线版免费视频大全| 国产精品99久久精品爆乳| 国产日韩精品一区二区三区在线| 国产96在线 | 韩国| 色哟哟免费视频播放网站| 少妇与子乱毛片| 中文字幕无码av波多野吉衣| 亚洲最大日夜无码中文字幕| 亚洲 欧美 另类 综合 日韩| 亚洲熟妇av综合网五月| 女人高潮抽搐喷液30分钟视频| 国产精品久免费的黄网站| 2019久久视频这里有精品15| 国产女厕所盗摄老师厕所嘘嘘| 四川丰满少妇被弄到高潮| 国产va在线观看免费| 麻豆国产在线精品国偷产拍 | 丝袜高潮流白浆潮喷在线播放 | 伦伦影院午夜理论片| 三级在线看中文字幕完整版| 久久99亚洲含羞草影院| 亚洲国产成人久久精品99| 国产香蕉尹人视频在线| 亚洲精品久久久蜜桃| 成人国产精品无码网站| 国产精品自在在线午夜免费 | 丰满少妇被猛烈进入高清播放 | 麻豆专媒体一区二区|