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NDUFS3 Recombinant Monoclonal Antibody

  • 中文名稱：
    NDUFS3重組抗體
  • 貨號：
    CSB-RA224121A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, HepG2 whole cell lysate,
      All lanes: NDUFS3 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 31, 15 KDa
      Observed band size: 31 kDa
    • IHC image of CSB-RA224121A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA224121A0HU NDUFS3重組單克隆抗體是針對線粒體復合物I核心亞基NDUFS3研發的高特異性檢測工具。該靶標作為線粒體呼吸鏈復合物I（NADH脫氫酶）的重要組成部分，直接參與細胞氧化磷酸化過程，在能量代謝穩態維持中發揮關鍵作用。本抗體采用重組技術制備，經ELISA、Western blot（WB）和免疫組化（IHC）多平臺驗證，在WB實驗中可識別天然構象的NDUFS3蛋白，推薦稀釋度1:500-1:5000范圍內均顯示清晰單一目標條帶；IHC應用在1:50-1:200稀釋條件下能精準定位線粒體區域，適用于石蠟包埋組織切片的亞細胞結構分析。其高親和力和低交叉反應性特點，使之成為研究線粒體功能調控、能量代謝異常相關疾病機制（如神經退行性疾病、代謝綜合征）的重要工具，可廣泛用于細胞生物學模型構建、蛋白互作研究及病理狀態下的分子表達分析等基礎科研領域。產品嚴格進行批次間質控，確保實驗數據的可重復性和可靠性。
  • Uniprot No.：
  • 基因名：
  • 別名：
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit), NDUFS3
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human NDUFS3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1H12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
  • 基因功能參考文獻：
    1. identified a novel Leigh syndrome causing NDUFS3 mutation and expanded the clinical spectrum caused by NDUFS3 mutations in this study. PMID: 30140060
    2. The results suggest that the impaired mitochondrial activity could be due to the broken interaction between DJ-1 and NDUFS3 and that downregulation of DJ-1 in sperm and testes contributes to AS pathogenesis. PMID: 29849492
    3. The NDUFS3 expressed in the temporal cortex in patient with late-onset Alzheimer's disease. PMID: 28242297
    4. High NDUFS3 expression is associated with IgA nephropathy. PMID: 25770168
    5. pH stability of w-t and Leigh syndrome mutant varied at extreme acidic pH. the molten globule like structure of w-t at pH1 was absent in case of the mutant protein. Both the w-t and mutant proteins showed multi-step thermal and Gdn-HCl induced unfolding PMID: 24028823
    6. NDUFS3 is down-regulated in serous ovarian adenocarcinoma PMID: 23446378
    7. Expressions of GRIM-19, NDUFS3, and extracellular matrix elements are correlated with invasive capabilities of breast cancer cell lines. PMID: 23630608
    8. a novel, biomarker potential of a mitochondrial complex I subunit protein, NDUFS3 - as a robust indicator of breast cancer progression and invasiveness as well as of hypoxia/necrosis in clinical specimens of invasive ductal carcinoma, was uncovered. PMID: 21867691
    9. Decreased protein levels of complex I 30-kDa subunit in fetal Down syndrome brains. PMID: 11771736

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  • 亞細胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    Complex I 30 kDa subunit family
  • 數據庫鏈接：

    HGNC: 7710

    OMIM: 603846

    KEGG: hsa:4722

    STRING: 9606.ENSP00000263774

    UniGene: Hs.502528



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